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Rabbit Anti-TSLP  antibody (bs-0449R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-0449R
英文名称 TSLP
中文名称 胸腺基质淋巴细胞生成素-1抗体
别    名 Thymic stromal lymphopoietin; Thymic stromal lymphopoietin isoform 1; Thymic stromal lymphopoietin protein TSLP; TSLP protein; TSLP_HUMAN.  
Specific References  (4)     |     bs-0449R has been referenced in 4 publications.
[IF=5.34] Dian-Dong Hou. et al. Therapeutic effects of myricetin on atopic dermatitis in vivo and in vitro. PHYTOMEDICINE. 2022 Jul;102:154200  IHC ;  Mouse.  
[IF=3.483] Shen Z et al. Insights into Roseburia intestinalis which alleviates experimental colitis pathology by inducing anti-inflammatory responses. J Gastroenterol Hepatol. 2018 Oct;33(10):1751-1760.  IHC-P ;  Mouse.  
[IF=2.493] Min-jie Gong. et al. Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly. IMMUN INFLAMM DIS. 2023 Feb;11(2):e788  WB ;  Human.  
[IF=0.67] Sakitani, Eri, et al. "Increased Expression of Thymic Stromal Lymphopoietin and Its Receptor in Kimuras Disease." ORL 77.1 (2015): 44-54.  other ;  
研究领域 细胞生物  免疫学  细胞因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 15kDa
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TSP-1: 101-159/159 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Thymic stromal lymphopoietin (TSLP) is a novel cytokine that was found to promote the development of murine B cells in vitro. This protein, which is expressed in a number of tissues including heart, liver and prostate, prevented apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ-3. Anti-interleukin (IL)-7 receptor antibodies (Abs) neutralized this effect indicating that TSLP binds to at least part of the IL-7 receptor complex. TSLP induced phosphorylation of signal transducer and activator of transcription (STAT)-5.

Function:
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

Subunit:
Interacts with a receptor composed of CRLF2 and IL7R.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in a number of tissues including heart, liver and prostate.

SWISS:
Q969D9

Gene ID:
85480

Database links:

Entrez Gene: 85480 Human

Entrez Gene: 53603 Mouse

Entrez Gene: 688621 Rat

Omim: 607003 Human

SwissProt: Q969D9 Human

SwissProt: Q9JIE6 Mouse

Unigene: 389874 Human

Unigene: 143716 Mouse

Unigene: 201724 Rat



胸腺基质淋巴细胞生成素-1(胸腺基质细胞分泌的淋巴细胞生成素-1)
为一种新型促进生长的细胞因子——胸腺基质淋巴蛋白(TSLP)可以引发炎症反应, 这种炎症反应可以引起很多过敏性疾病和哮喘。
TSLP可能是过敏性疾病最重要的引发剂,已得到科学家的重视,如果证实了 TSLP是一种起始因子,抑制TSLP可以有效地治疗哮喘和其它过敏性疾病。
产品图片
Sample: Lane1:K562 Cell Lysate at 30ug Lane2: Raji Cell Lysate at 30ug Primary: Anti-TSLP (bs-0449R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution; Predicted band size: 15 kD Observed band size: 17 kD
Tissue/cell: human liver carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-TSLP Polyclonal Antibody, Unconjugated(bs-0449R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TSLP) Polyclonal Antibody, Unconjugated (bs-0449R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Human heart); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TSLP) Polyclonal Antibody, Unconjugated (bs-0449R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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