扫码关注公众号           扫码咨询技术支持           扫码咨询技术服务
  
客服热线:400-901-9800  客服QQ:4009019800  技术答疑  技术支持  质量反馈  人才招聘  关于我们  联系我们
产品中心-北京博奥森生物技术有限公司
首页 > 产品中心 > 一抗 > 产品信息
Rabbit Anti-E-Selectin  antibody (bs-1273R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购QQ:  400-901-9800
技术支持:techsupport@bioss.com.cn
说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-1273R
英文名称 E-Selectin
中文名称 E选择素抗体
别    名 CD 62E; CD26E; CD62E antigen; CD62 antigen-like family member E; E selectin; ELAM 1; ELAM; ELAM-1; ELAM1; Endothelial adhesion molecule 1; Endothelial leukocyte adhesion molecule 1; ESEL; LECAM 2; LECAM2; Leukocyte endothelial cell adhesion molecule 2; Leukocyte-endothelial cell adhesion molecule 2; LYAM2_HUMAN; SELE; Selectin E; SelectinE.  
Specific References  (17)     |     bs-1273R has been referenced in 17 publications.
[IF=6.408] Zhao, Lixin. et al. A nanozyme-based competitive electrochemical immunosensor for the determination of E-selectin. MICROCHIM ACTA. 2022 Nov;189(11):1-10  Other ;  Human.  
[IF=5.201] Qian Liet al. LOX-1 Regulates P. gingivalis-Induced Monocyte Migration and Adhesion to Human Umbilical Vein Endothelial Cells. Front Cell Dev Biol . 2020 Jul 14;8:596.  WB ;  Human.  
[IF=5.118] Masahiro Terasawa. et al. Anti-Inflammatory Activity of Orally Administered Monostroma nitidum Rhamnan Sulfate against Lipopolysaccharide-Induced Damage to Mouse Organs and Vascular Endothelium. Mar Drugs. 2022 Feb;20(2):121  IHC ;  Mouse.  
[IF=4.556] Chou K et al. Secretome of Hypoxic Endothelial Cells Stimulates Bone Marrow-Derived Mesenchymal Stem Cells to Enhance Alternative Activation of Macrophages. Int J Mol Sci. 2020 Jun 21;21(12):4409.  Other ;  Mouse.  
[IF=4.545] Zhixiong Li et al. Shuxuening injection facilitates neurofunctional recovery via down-regulation of G-CSF-mediated granulocyte adhesion and diapedesis pathway in a subacute stroke Mousemodel. Biomed Pharmacother. 2020 Jul;127:110213.  WB ;  Mouse.  
[IF=4.486] Wang X et al. Crosstalk between Akt and NF‐κB pathway mediates inhibitory effect of gas6 on monocytes‐endothelial cells interactions stimulated by P. gingivalis‐LPS. J Cell Mol Med. 2020 Jul;24(14):7979-7990.  WB ;  Human.  
[IF=4.486] Wang X et al. Crosstalk between Akt and NF‐κB pathway mediates inhibitory effect of gas6 on monocytes‐endothelial cells interactions stimulated by P. gingivalis‐LPS. J Cell Mol Med . 2020 Jul;24(14):7979-7990.  WB ;  Human.  
[IF=3.99] Naito, Chisato, et al. "Facilitatory effects of fetuin-A on atherosclerosis."Atherosclerosis (2016).  WB ;  Human.  
[IF=3.96] Zhang, Zhuochao, et al. "Cytokine profiles in Tibetan macaques following α‐1, 3‐galactosyltransferase‐knockout pig liver xenotransplantation." Xenotransplantation (2017).  IHC-P ;  Pig.  
[IF=3.74] Zhang, Shengye, et al. "Role of the plasma cascade systems in ischemia/reperfusion injury of bone." Bone (2017).  IHC-P ;  Rat.  
[IF=3.512] Wen Xiong. et al. Mechanisms and Molecular Targets of BuShenHuoXue Formula for Osteoarthritis. Acs Omega. 2022;7(5):4703–4713  WB ;  Rat.  
[IF=3.38] Chou, Kang-Ju, et al. "CD44 Fucosylation on Mesenchymal Stem Cell Enhances Homing and Macrophage Polarization in Ischemic Kidney Injury." Experimental Cell Research (2016).  WB ;  Mouse.  
[IF=2.976] Peng Y et al. Sonodynamic therapy improves anti‑tumor immune effect by increasing the infiltration of CD8+ T cells and altering tumor blood vessels in murine B16F10 melanoma xenograft. Oncol Rep. 2018 Oct;40(4):2163-2170.   IHF ;  Mouse.  
[IF=2.02] Kong, Lingxi, et al. "The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits." Lipids in Health and Disease 12.1 (2013): 115.  IHC-P ;  Rabbit.  
[IF=1.287] Na Li. et al. SELE gene as a characteristic prognostic biomarker of colorectal cancer:. J Int Med Res. 2021;49(4):  IHC ;  Human.  
[IF=0.14] Tu, Q., et al. "Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects." Neural Regeneration Research 9.3 (2014): 268.  IHC-P ;  Rat.  
[IF=0] Wei, Min Jun, et al. "Identification of OPN, TNC and E-selectin as potential recognition proteins in cerebral vasospasm after subarachnoid hemorrhage."Chinese Neurosurgical Journal 2.1 (2016): 1.  WB, IHC-P ;  Human, Rat.  
研究领域 细胞生物  免疫学  细胞粘附分子  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,Mouse,Pig (predicted: Rat,Chicken,Dog,Horse,Rabbit)
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 65kDa
检测分子量 115 kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse E-Selectin: 501-612/612 <Cytoplasmic>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

Function:
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Subunit:
Interacts with PSGL1/SELPLG through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 6 Sushi (CCP/SCR) domains.

SWISS:
Q00690

Gene ID:
20339

Database links:

Entrez Gene: 6401 Human

Entrez Gene: 20339 Mouse

Entrez Gene: 25544 Rat

Omim: 131210 Human

SwissProt: P16581 Human

SwissProt: Q00690 Mouse

SwissProt: P98105 Rat

Unigene: 82848 Human

Unigene: 5245 Mouse

Unigene: 10359 Rat



E选择素(CD62E)是活化的内皮细胞表面表达的黏附分子,是白细胞与内皮细胞形成接触时的启动因子。E选择素是表达在血管内皮细胞表面的黏附分子。
产品图片
Sample: Siha Cell Lysate at 40 ug
Primary: Anti- E-Selectin (bs-1273R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 65 kD
Observed band size: 65 kD
Sample: Liver (Mouse) Lysate at 40 ug
Primary: Anti- E-Selectin (bs-1273R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 65 kD
Observed band size: 65 kD
Sample: HL-60 Cell (Human) Lysate at 40 ug
Primary: Anti- E-Selectin (bs-1273R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 65 kD
Observed band size: 65 kD
Sample:
DU145 Cell Lysate at 40 ug
LOVO Cell Lysate at 40 ug
Primary: Anti-E-Selectin (wt-p53)(bs-1273R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 65 kD
Observed band size: 63 kD
版权所有 2004-2026 www.bioss.com.cn 北京博奥森生物技术有限公司
通过国际质量管理体系ISO 9001:2015 GB/T 19001-2016    认证编号: 00122Q31509R1M/1100
京ICP备05066980号-1         京公网安备110107000727号