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Rabbit Anti-uPA Receptor antibody (bs-1927R)
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说明书: 50ul  100ul  200ul
50ul/980.00元
100ul/1680.00元
200ul/2480.00元
大包装/询价

产品编号 bs-1927R
英文名称 uPA Receptor
中文名称 尿激酶型纤溶酶原激活因子受体抗体
别    名 PLAUR; Plasminogen activator,urokinase receptor; Urokinase plasminogen activator surface receptor; Monocyte activation antigen Mo3; uPAR; U-PAR; MO3; UPAR; CD 87; CD87; CD87 antigen; MO 3; MO3; Monocyte activation antigen Mo3; Plasminogen activator urokinase receptor; U PAR; u plasminogen activator receptor; UPA receptor; UPAR; Urinary plasminogen activator receptor; URKR; Urokinase plasminogen activator receptor; Urokinase plasminogen activator surface receptor.   
研究领域 肿瘤  心血管  细胞生物  免疫学  信号转导  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Sheep, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
细胞定位 细胞膜 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PLAUR:201-300/335 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol(GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq].

Function:
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Subcellular Location:
Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Secreted (Probable).

Tissue Specificity:
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Similarity:
Contains 3 UPAR/Ly6 domains.

SWISS:
Q03405

Gene ID:
5329

Database links:

Entrez Gene: 5329 Human

Entrez Gene: 18793 Mouse

Entrez Gene: 50692 Rat

Omim: 173391 Human

SwissProt: Q03405 Human

SwissProt: P35456 Mouse

SwissProt: P49616 Rat

Unigene: 466871 Human

Unigene: 1359 Mouse

Unigene: 82711 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片
Sample:
bone (Mouse) Lysate at 40 ug
Primary: Anti-uPA Receptor (bs-1927R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 48 kD
Tissue/cell: mouse adrenal gland; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-uPA Receptor Polyclonal Antibody, Unconjugated(bs-1927R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: mouse brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-uPA Receptor Polyclonal Antibody, Unconjugated(bs-1927R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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