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Rabbit Anti-HAVCR1  antibody (bs-2713R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-2713R
英文名称 HAVCR1
中文名称 肾损伤分子1/甲型肝炎病毒细胞受体1抗体
别    名 HAVCR; HAVCR 1; HA; Vcr-1; hepatitis A virus cellular receptor 1; HKIM-1; Kidney Injury Molecule1; KIM1; KIM 1; KIM-1; TIM-1; TIMD 1; TIMD1; KM-1; TIMD1_HUMAN; T cell immunoglobin domain and mucin domain protein 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell membrane protein 1.  肾脏损伤分子1
Specific References  (14)     |     bs-2713R has been referenced in 14 publications.
[IF=11.556] Wen-juan Jiang. et al. Tubular epithelial cell-to-macrophage communication forms a negative feedback loop via extracellular vesicle transfer to promote renal inflammation and apoptosis in diabetic nephropathy. Theranostics. 2022; 12(1): 324–339  WB ;  Mouse,Human.  
[IF=9.473] Xiao-yan He. et al. Cpd-42 Alleviates Acute Kidney Injury via Targeting RIPK3-mediated Necroptosis. BRIT J PHARMACOL. 2023 May;:  IHC,WB ;  Mouse.  
[IF=7.31] Huang Yue-bo. et al. Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis. OXID MED CELL LONGEV. 2022;2022:4776243  IHC, IF ;  Mouse.  
[IF=6.691] Jiang, Wenjuan. et al. Macrophage-derived, LRG1-enriched extracellular vesicles exacerbate aristolochic acid nephropathy in a TGFβR1-dependent manner. 2021 Oct 22  WB,IF ;  Mouse.  
[IF=6.304] Zhu H et al. PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cellsCell Death Dis.2020 Dec 12;11(12):1057.  IF、WB ;  Mouse.  
[IF=5.275] Ming-jun Yu. et al. Discovery of a Novel GRPR Antagonist for Protection against Cisplatin-Induced Acute Kidney Injury. BIOORG CHEM. Bioorg Chem. 2022 Apr;:105794  WB ;  Mouse,Human.  
[IF=5.085]   WB , IF ;  
[IF=5.064] Fang Wang. et al. Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis. Acta Pharmacol Sin. 2021 Apr;:1-12  WB,IF,IHC ;  Human, Mouse.  
[IF=3.448] Topdağı Ö et al. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life Sci. 2020 Feb 1;242:117217.  IHC ;  Rat.  
[IF=3.292] Ademola Adetokunbo Oyagbemi. et al. Luteolin supplementation ameliorates cobalt-induced oxidative stress and inflammation by suppressing NF-кB/Kim-1 signaling in the heart and kidney of rats. Environ Toxicol Phar. 2020 Nov;80:103488  IHC ;  Rat.  
[IF=3.222] Pengmin Ji. et al. Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice. RENAL FAILURE. 2023;45(1):Article: 2197075  WB ;  Mouse.  
[IF=2.491] Oyagbemi AA et al. Ameliorative effect of Rutin on sodium fluoride‐induced hypertension through modulation of Kim‐1/NF‐κB/Nrf2 signaling pathway in rats.(2018)Environ Toxicol.  IHC ;  Rat.  
[IF=1.718] Selim Çomaklı. et al. Morin mitigates ifosfamide induced nephrotoxicity by regulation of NF-kappaB/p53 and Bcl-2 expression. 2022 Jan 17  IHC ;  Rat.  
[IF=0] Gülden Diniz. et al. Tissue Expression of Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Breast Cancers.. European Journal of Breast Health. 2022 Oct;18(4):336-342  IHC ;  Human.  
研究领域 细胞生物  免疫学  细胞膜受体  细菌及病毒  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,Human (predicted: Cow,Pig,Dog,Rat)
产品应用 WB=1:500-2000, Flow-Cyt=1ug/test, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 39kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HAVCR1: 51-150/359 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Function:
May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair.

Subcellular Location:
Membrane; Single-pass type I membrane protein (Probable).

Tissue Specificity:
Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.

Similarity:
Belongs to the immunoglobulin superfamily. TIM family. Contains 1 Ig-like V-type (immunoglobulin-like)

SWISS:
Q96D42

Gene ID:
26762

Database links:

Entrez Gene: 26762 Human

Entrez Gene: 171283 Mouse

Entrez Gene: 286934 Rat

Omim: 606518 Human

SwissProt: Q96D42 Human

SwissProt: Q5QNS5 Mouse

SwissProt: O54947 Rat

Unigene: 129711 Human

Unigene: 17771 Mouse

Unigene: 11154 Rat



产品图片
Blank control: A549.
Primary Antibody (green line): Rabbit Anti-HAVCR1c antibody (bs-2713R)
Dilution: 3μg /10^6 cells;
Isotype Control Antibody (orange line): Rabbit IgG .
Secondary Antibody : Goat anti-rabbit IgG-PE
Dilution: 3μg /test.
Protocol
The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
Blank control:HepG2.
Primary Antibody (green line): Rabbit Anti-HAVCR1c/TIM 1 antibody (bs-2713R)
Dilution: 1ug/Test;
Secondary Antibody (white blue line) : Goat anti-rabbit IgG-AF488
Dilution: 0.5ug/Test.
Isotype control(orange line):Normal Rabbit IgG
Protocol
The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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