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Rabbit Anti-SMO antibody (bs-2801R)
~~~促销,代码SSY221101~~~
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说明书: 50ul  100ul  200ul
50ul/1098.00元
100ul/1880.00元
200ul/2900.00元
大包装/询价
产品编号 bs-2801R
英文名称 SMO
中文名称 跨膜蛋白Smoothened抗体
别    名 Gx; Gx protein; Smoothened; SMOH; Smoothened homolog (Drosophila); Smoothened homolog; Smoothened homolog precursor (SMO) (Gx protein); SMO_HUMAN.  
Specific References  (7)     |     bs-2801R has been referenced in 7 publications.
[IF=1.26] Li H et al. Rosmarinic acid inhibits stem-like breast cancer through hedgehog and Bcl-2/Bax signaling pathways. Pharmacognosy Magazine,2019 15(65): 600-606.  WB ;  Human.  
[IF=4.069] Sato Y et al. Blockade of Hedgehog Signaling Attenuates Biliary Cystogenesis in the Polycystic Kidney (PCK) Rat.Am J Pathol. 2018 Oct;188(10):2251-2263.  IHC-P&ICF ;  Rat.  
[IF=3.361] Chen X et al. Hesperetin derivative attenuates CCl4-induced hepatic fibrosis and inflammation by Gli-1-dependent mechanisms. Int Immunopharmacol. 2019 Aug 29;76:105838.  WB ;  Mouse.  
[IF=2.192] Abdelhamed et al. Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma. (2018) Int.J.Gynecol.Cancer. 28:1535-1544  IF,IHC ;  Human.  
[IF=4.26] Zhou et al. GDC-0449 improves the antitumor activity of nano-doxorubicin in pancreatic cancer in a fibroblast-enriched microenvironment. (2017) Sci.Rep. 7:13379  WB ;  Human.  
[IF=10.042] Liu et al. Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. (2016) Genes.Dev. 30:1943-55  IHC ;  Mouse.  
[IF=4.56] Wang, H., et al. "Baicalin Attenuates Alcoholic Liver Injury through Modulation of Hepatic Oxidative Stress, Inflammation and Sonic Hedgehog Pathway in Rats." Cellular Physiology and Biochemistry 39.3 (2016): 1129-1140.  WB ;  Rat.  
研究领域 肿瘤  免疫学  信号转导  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 84kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SMO: 551-650/787 <Cytoplasmic>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]

Function:
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

Subunit:
Interacts with ARRB2. Interacts with KIF7.

Subcellular Location:
Membrane.

Similarity:
Belongs to the G-protein coupled receptor Fz/Smo family.
Contains 1 FZ (frizzled) domain.

SWISS:
Q99835

Gene ID:
6608

Database links:

Entrez Gene: 6608 Human

Entrez Gene: 319757 Mouse

Entrez Gene: 25273 Rat

SwissProt: Q99835 Human

SwissProt: P56726 Mouse

SwissProt: P97698 Rat

Unigene: 437846 Human

Unigene: 29279 Mouse

Unigene: 44429 Rat



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