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Rabbit Anti-Radixin antibody (bs-3808R)
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说明书: 100ul  200ul
100ul/1380.00元
200ul/2200.00元
大包装/询价
产品编号 bs-3808R
英文名称 Radixin
中文名称 根蛋白抗体
别    名 ESP10; Hh-induced MATH and BTB domain-containing protein; HIB; Moesin-B; Protein roadkill; Radixin; rdx; CB567; CG12537; DFNB24; RADI_HUMAN.  
规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
说 明 书 100ul  200ul
研究领域 细胞生物  免疫学  细胞表面分子  上皮细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 69kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Radixin:25-130/583 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Function:
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane.

Subunit:
Binds SLC9A3R1. Interacts with NHERF1, NHERF2, LAYN, MME/NEP and ICAM2

Subcellular Location:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.

Post-translational modifications:
Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding

DISEASE:
Defects in RDX are the cause of deafness autosomal recessive type 24 (DFNB24) [MIM:611022]. DFNB24 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Similarity:
Contains 1 FERM domain.

SWISS:
P35241

Gene ID:
5962

Database links:

Entrez Gene: 5962 Human

Entrez Gene: 19684 Mouse

Entrez Gene: 315655 Rat

Omim: 179410 Human

SwissProt: P35241 Human

SwissProt: P26043 Mouse

Unigene: 263671 Human

Unigene: 592679 Human

Unigene: 245746 Mouse

Unigene: 472057 Mouse

Unigene: 224619 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

根蛋白是一种细胞骨架蛋白,在连接肌动蛋白于质膜中可能有重要作用。研究表明,根蛋白对于结合胆红素通过其Mrp2在BCMs中定位支持的分泌是需要的。埃兹蛋白-根蛋白-膜突蛋白家族蛋白是亚膜皮质,特别是上皮细胞中普遍存在的成分。其可能参与将肌动蛋白丝的顶端锚定于胞膜。
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