| 产品编号 | bs-5083R |
| 英文名称 | MTTP |
| 中文名称 | 微粒体甘油三酯转运蛋白 |
| 别 名 | ABL; Microsomal triglyceride transfer protein (large polypeptide 88kDa); Microsomal triglyceride transfer protein 88kD; Microsomal triglyceride transfer protein; Microsomal triglyceride transfer protein large subunit; MTP; MTP large subunit; MTP_HUMAN; MTTP; Transfer RNA, mitochondrial, proline; tRNA-Pro, mitochondrial; Microsomal triglyceride transfer protein large; Microsomal triglyceride transfer protein large Precursor; microsomal triglyceride transfer protein large subunit precursor. |
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Specific References (1) | bs-5083R has been referenced in 1 publications.
[IF=3.352] Rongxue Wei. et al. Study on the Effect of Different Types of Sugar on Lipid Deposition in Goose Fatty Liver. Poultry Sci. 2022 Jan;:101729 WB ; Goose.
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| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 信号转导 脂蛋白 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Rat (predicted: Human,Mouse,Pig,Cow,Horse,Rabbit,GuineaPig) |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 97kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MTTP: 801-900/894 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
MTTP catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. MTTP is required for the secretion of plasma lipoproteins that contain apolipoprotein B. It is positively regulated by cholesterol and negatively regulated by insulin. Defects in MTP are the cause of abetalipoproteinemia. Function: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Subunit: Heterodimer composed of MTTP and of protein disulfide isomerase (P4HB/PDI) (By similarity). Subcellular Location: Endoplasmic reticulum. Tissue Specificity: Liver and small intestine. Also found in ovary, testis and kidney. DISEASE: Abetalipoproteinemia (ABL) [MIM:200100]: An autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 1 vitellogenin domain. SWISS: P55157 Gene ID: 4547 Database links: Entrez Gene: 100734244 Guinea pig Entrez Gene: 100053803, Horse Entrez Gene: 4547 Human Entrez Gene: 17777 Mouse Entrez Gene: 100341961 Rabbit Omim: 590075 Human SwissProt: P55157 Human SwissProt: O08601 Mouse Unigene: 195799 Human Unigene: 2941 Mouse Unigene: 81556 Rat 微粒体甘油三酯转移蛋白（microsomal triglyceride transfer protein，MTP）是一种主要分布于肝细胞、肠上皮细胞中的脂质转移蛋白，存在于细胞微粒体、内质网腔内，在内质网内含量最高，占总蛋白的0．5％-1．0％,MTTP在甘油三酯转运及极低密度脂蛋白组装和分泌中发挥着重要作用。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
