| 产品编号 | bs-5129R |
| 英文名称 | ITLN1 Rabbit pAb |
| 中文名称 | 内皮细胞凝集素HL1抗体 |
| 别 名 | Endothelial lectin HL 1; Endothelial lectin HL-1; Galactofuranose binding lectin; Galactofuranose-binding lectin; hIntL; HL 1; HL1; Intelectin; Intelectin 1; Intelectin-1; Intestinal lactoferrin receptor; INTL; ITLN; ITLN-1; ITLN1; ITLN1_HUMAN; LFR; Omentin. |
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Specific References (2) | bs-5129R has been referenced in 2 publications.
[IF=6.6] Xiaoran Fu. et al. The Effect of Mineralocorticoid Receptor 3 Antagonists on Anti-Inflammatory and Anti-Fatty Acid Transport Profile in Patients with Heart Failure. CELLS-BASEL. Cells-Basel. 2022 Jan;11(8):1264 IHC ; Human.
[IF=4.87] Liu H et al. Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in MPTP‐induced Parkinson's disease in mice. J Neurochem. 2019 Aug 23. IHC&WB ; Mouse.
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| 研究领域 | 心血管 细胞生物 免疫学 发育生物学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | Human,Mouse (predicted: Rat,Pig,Cow,Horse) |
| 产品应用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 35 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞膜 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ITLN1: 131-230/313 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
ITLN1 (Intelectin 1) is a Protein Coding gene. Diseases associated with ITLN1 include Obesity and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Innate Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is ITLN2. Function: Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499). Subunit: Homotrimer; disulfide-linked. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Enriched in lipid rafts. Tissue Specificity: Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus. Post-translational modifications: N-glycosylated. Similarity: Contains 1 fibrinogen C-terminal domain. SWISS: Q8WWA0 Gene ID: 55600 Database links: Entrez Gene: 55600 Human Omim: 609873 Human SwissProt: Q8WWA0 Human Unigene: 50813 Human |
| 产品图片 |
Sample: heart (mouse) Lysate at 40 ug
Primary: Anti- ITLN1(bs-5129R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 35kD
Observed band size: 35kD
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
