| 产品编号 | bs-0076P |
| 英文名称 | Aβ42 (35-42) Antibody Blocking Peptide |
| 中文名称 | β淀粉样肽1-42(C端)封闭多肽 |
| 别 名 | β-Amyloid 1-42; beta Amyloid(1-42); beta Amyloid 1-42; beta-Amyloid 1-42; Amyloid 1-42; A4; AAA; ABETA; ABPP; AD1; Alzheimers Disease Amyloid Protein; Amyloid B; Amyloid Beta A4 Protein Precursor; Amyloid Beta; Amyloid of Aging and Alzheimer Disease; APP; APPI; B Amyloid; Beta APP; Cerebral Vascular Amyloid Peptide; CTFgamma; CVAP; PN II; PN2; PreA4; Protease nexin II; A beta; A4_HUMAN. |
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Specific References (3) | bs-0076P has been referenced in 3 publications.
[IF=7.632] Dongmiao Qin. et al. Design of a Dual-Wavelength Ratiometric Electrochemiluminescence Immunosensor for Sensitive Detection of Amyloid-β Protein in Human Serum. Acs Sustain Chem Eng. 2021;9(22):7541–7549 Other ;
[IF=6.408] Qin, Dongmiao. et al. Construction of efficient electrochemiluminescence resonance energy transfer sensor based on SnO2/SnS2QDs-Ru@IRMOF-3 composite for sensitive detection of procalcitonin. MICROCHIM ACTA. 2022 Nov;189(11):1-15 Other ; Other.
[IF=3.61] Jiasi Yu. et al. Study on multi-target effects of PIMPC on Aβ/Cu2+-induced Alzheimer's disease model of rats. BRAIN RES. 2023 Mar;1802:148226
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| 理论分子量 | kDa |
| 检测分子量 | |
| 性 状 | Lyophilized |
| 物 种 | human |
| 纯化方法 | HPLC |
| 活性 | Not tested |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 产品介绍 |
The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimer's disease. Beta-Amyloid 也称Beta-A4 蛋白，是Beta-淀粉样蛋白前体（APP）经Beta和Gamma分泌酶分解后的产物。是淀粉样蛋白的主要成分。此蛋白在大脑中形成不容性的沉积物(老年斑),从而具有特殊的AD,Down's综合症和老年痴呆症的形态学特征. Beta-淀粉样蛋白来自Beta-淀粉样蛋白原，在脑组织的细胞外呈丝状蛋白样沉积 是淀粉样结节性神经炎病变的主要蛋白成分，在神经纤维中也有沉积。 Beta-Amyloid1-42在老年性痴呆Alzheimer病中，大脑皮质中特征性地出现Beta-淀粉样蛋白沉积形成的老年斑。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
