| 产品编号 | bs-5765R |
| 英文名称 | LANCL2 |
| 中文名称 | G蛋白偶联受体69B |
| 别 名 | G protein coupled receptor 69B; LanC (bacterial lantibiotic synthetase component C) like 2; TASP; Testis specific adriamycin sensitivity protein; LANC2_HUMAN. |
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Specific References (1) | bs-5765R has been referenced in 1 publications.
[IF=3.37] Dylan Maixner. et al. Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord :. MOL PAIN. 0;(): WB ; Rat.
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| 研究领域 | 肿瘤 免疫学 染色质和核信号 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Mouse,Rat,Chicken,Dog,Rabbit) |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 51kDa |
| 细胞定位 | 细胞核 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LANCL2: 331-430/460 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
LANCL2 belongs to the LanC like protein family. It is expressed in the brain and testis. LANCL2 is a bystander gene coamplified and overexpressed with epidermal growth factor receptor (EGFR) in 20% of all glioblastomas. Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin). Function: Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Subunit: Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association. Subcellular Location: Nucleus. Cytoplasm. Cell membrane. Note=Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo. Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin). Tissue Specificity: Expressed in brain and testis. Post-translational modifications: Myristoylated. Essential for membrane association. Similarity: Belongs to the LanC-like protein family. SWISS: Q9NS86 Gene ID: 55915 Database links: Entrez Gene: 55915 Human SwissProt: Q9NS86 Human Unigene: 595384 Human |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
