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Rabbit Anti-Renin  antibody (bs-6184R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-6184R
英文名称 Renin
中文名称 肾素/血管紧张素形成酶Ren1抗体
别    名 Angiotensin forming enzyme; Angiotensin forming enzyme precursor; Angiotensinogenase; Angiotensinogenase precursor; HNFJ2; REN; Renin1; Renin-1; Renin 1; Ren1; RENI_HUMAN; Renin; Renin precursor renal.   
Specific References  (9)     |     bs-6184R has been referenced in 9 publications.
[IF=5.11] Wanka, Heike, et al. "Anti-necrotic and cardioprotective effects of a cytosolic renin isoform under ischemia-related conditions." Journal of Molecular Medicine(2015): 1-9.  WB ;  Rat.  
[IF=5.1] Wu, Ka, et al. "Biocharacterization of Heat Shock Protein 90 in Acetaminophen-Treated Livers Without Conspicuous Drug Induced Liver Injury." Cellular Physiology and Biochemistry 43.4 (2017): 1-1.  IHC-P ;  Mouse.  
[IF=3.598] Xu X et al. Potential biomarker of fibroblast growth factor 21 in valproic acid-treated livers. Biofactors. 2019 May 23.  IHC-P ;  Mouse.  
[IF=3.448] Chen ZZ et al. Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting. Life Sci. 2019 Nov 20;240:117085.  IHC-P&WB ;  Rat.  
[IF=2.96] Jiamei Yao. et al. Comparative transcriptomic analysis revealed novel potential therapeutic targets of traditional Chinese medicine (Pinggan-Qianyang decoction) on vascular remodeling in spontaneously hypertensive rats. Chin Med-Uk. 2021 Dec;16(1):1-17  WB ;  Rat.  
[IF=2.81] Soto et al. Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system. (2017) PLoS.One. 12:e0183314  ELISA ;  Rat.  
[IF=1.92] Liu, Chen, et al. "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." BMC Cardiovascular Disorders 16.1 (2016): 192.  WB ;  Dog.  
[IF=1.785] Yongli Zhao. et al. Calcilytic NPS2143 promotes proliferation and inhibits apoptosis of spontaneously hypertensive rat vascular smooth muscle cells via activation of the renin‑angiotensin system. Exp Ther Med. 2020 Aug;20(2):818-829  WB,IF ;  Rat.  
[IF=1.41] R Sun et al. Calcimimetic R568 reduced the blood pressure and improved aortic remodeling in spontaneously hypertensive rats by inhibiting local renin‑angiotensin system activity.(2018),Experimental and Therapeutic Medicine. 16: 4089-4099  WB ;  Rat.  
研究领域 肿瘤  染色质和核信号  信号转导  转录调节因子  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,Rat (predicted: Human,Dog,Cow,Horse)
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 37kDa
细胞定位 细胞膜 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Renin: 331-406/406 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008].

Function:
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Subunit:
Interacts with ATP6AP2.

Subcellular Location:
Secreted. Membrane. Associated to membranes via binding to ATP6AP2.

DISEASE:
Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.

Similarity:
Belongs to the peptidase A1 family.

SWISS:
P00797

Gene ID:
5972

Database links:

Entrez Gene: 469651 Chimpanzee

Entrez Gene: 5972 Human

Entrez Gene: 19701 Mouse

Entrez Gene: 19702 Mouse

Entrez Gene: 24715 Rat

Omim: 179820 Human

SwissProt: P60016 Chimpanzee

SwissProt: Q6DLS0 Cynomolgus Monkey

SwissProt: P00797 Human

SwissProt: P00796 Mouse

SwissProt: P06281 Mouse

SwissProt: P08424 Rat

Unigene: 3210 Human

Unigene: 220955 Mouse

Unigene: 9831 Rat



产品图片
Sample:
Lane 1: Mouse Kidney Lysates
Lane 2: Rat Kidney Lysates
Primary: Anti-Renin (bs-6184R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 37kDa
Observed band size: 37kDa
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