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TLR7 Rabbit pAb (bs-6601R)  
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50ul/1180.00元
100ul/1980.00元
大包装/询价

产品编号 bs-6601R
英文名称 TLR7 Rabbit pAb
中文名称 Toll样受体7抗体
别    名 TLR-7; PRO285; TLR 7; TLR7_HUMAN; Toll like receptor 7; Toll-like receptor 7; UNQ248.  
Specific References  (5)     |     bs-6601R has been referenced in 5 publications.
[IF=10.419] Takashi Umeharaet al. A simple sperm-sexing method that activates TLR7/8 on X sperm for the efficient production of sexed Mouseor cattle embryos. Nat Protoc . 2020 Aug;15(8):2645-2667.  FCM ;  mouse.  
[IF=8.386] Umehara T et al. Activation of Toll-like receptor 7/8 encoded by the X chromosome alters sperm motility and provides a novel simple technology for sexing sperm. PLoS Biol. 2019 Aug 13;17(8):e3000398.  WB ;  Mouse.  
[IF=8.025] Fei Wen. et al. TLR7/8 agonist (R848) inhibit bovine X sperm motility via PI3K/GSK3α/β and PI3K/NFκB pathways. INT J BIOL MACROMOL. 2023 Mar;232:123485  IF ;  Bovine.  
[IF=3.777] Ling Shuai. et al. Hydroxychloroquine protects against autoimmune premature ovarian insufficiency by modulating the Treg/Th17 cell ratio in BALB/c mice. AM J REPROD IMMUNOL. 2023 Feb;:  WB ;  Mouse.  
[IF=1.72] Lu, Na-na, et al. "Gene Expression Profiles Underlying Selective T-Cell-Mediated Immunity Activity of a Chinese Medicine Granule on Mice Infected with Influenza Virus H1N1." Evidence-Based Complementary and Alternative Medicine 2014 (2014).  WB ;  Mouse.  
研究领域 细胞生物  免疫学  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 Human
产品应用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 121 kDa
检测分子量
细胞定位 细胞浆 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TLR7: 461-560/1049 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Subunit:
Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.

Tissue Specificity:
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

Similarity:
Belongs to the Toll-like receptor family.
Contains 27 LRR (leucine-rich) repeats.
Contains 1 TIR domain.

SWISS:
Q9NYK1

Gene ID:
51284

Database links:

Entrez Gene: 493686 Cow

Entrez Gene: 51284 Human

Entrez Gene: 170743 Mouse

Omim: 300365 Human

SwissProt: Q9NYK1 Human

SwissProt: P58681 Mouse

Unigene: 101913 Cow

Unigene: 659215 Human

Unigene: 23979 Mouse



产品图片
Sample: Lane 1: Human THP-1(LPS) cell lysates Lane 2: Human THP-1 cell lysates Lane 3: Human Jurkat cell lysates Lane 4: Human MCF-7 cell lysates Lane 5: Human 293T cell lysates Primary: Anti-TLR7 (bs-6601R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 121 kDa Observed band size: 65,121 kDa
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