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Rabbit Anti-HSD17B1  antibody (bs-6603R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购QQ:  400-901-9800
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-6603R
英文名称 HSD17B1
中文名称 羟类固醇脱氢酶17β抗体
别    名 17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; DHB1_HUMAN; E2DH; EDH17B2; EDHB17; Estradiol 17 beta dehydrogenase 1; Estradiol 17-beta-dehydrogenase 1; HSD17; HSD17B1; Hydroxysteroid (17 beta) dehydrogenase 1; Placental 17 beta hydroxysteroid dehydrogenase; Placental 17-beta-hydroxysteroid dehydrogenase.  
Specific References  (1)     |     bs-6603R has been referenced in 1 publications.
[IF=8.469] Xiaofeng Zhou. et al. DNA methylation mediated RSPO2 to promote follicular development in mammals. Cell Death Dis. 2021 Jun;12(7):1-13  WB ;  Pig.  
研究领域 肿瘤  神经生物学  信号转导  生长因子和激素  内分泌病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse (predicted: Human,Rat,Dog,Pig,Cow,Horse,Rabbit)
产品应用 WB=1:500-2000, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 36kDa
细胞定位 细胞浆 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HSD17B1: 21-120/328 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Function:
Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Subunit:
Homodimer.

Subcellular Location:
Cytoplasm.

Similarity:
Belongs to the short-chain dehydrogenases/reductases

SWISS:
P14061

Gene ID:
3292

Database links:

Entrez Gene: 3292 Human

Omim: 109684 Human

SwissProt: P14061 Human

Unigene: 654385 Human

Unigene: 655222 Human



产品图片
Sample: Ovary (Mouse) Lysate at 40 ug
Primary: Anti-HSD17B1 (bs-6603R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 36 kD
Sample: Placenta (Mouse) Lysate at 40 ug
Primary: Anti-HSD17B1 (bs-6603R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 38 kD
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