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Rabbit Anti-Thrombospondin 2  antibody (bs-7524R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-7524R
英文名称 Thrombospondin 2
中文名称 血小板反应蛋白2/凝血酶敏感蛋白2抗体
别    名 THBS2; Thrombospondin-2; Thrombospondin2; TSP2; TSP2_HUMAN.  
Specific References  (3)     |     bs-7524R has been referenced in 3 publications.
[IF=4.638] Li Jianxiong. et al. Whole-exome mutational landscape and molecular marker study in mucinous and clear cell ovarian cancer cell lines 3AO and ES2. BMC CANCER. 2023 Dec;23(1):1-13  WB,IF ;  Human.  
[IF=2.22] Ken-Go Hayashi. et al. Differential expression of pro- and anti-angiogenic factors in the endometrium between repeat breeder and normally fertile cows. ANIM REPROD SCI. 2023 Jul;254:107265  IHC ;  Bovine.  
[IF=1.33] Chen, Junying, et al. "MiR-1246 promotes SiHa cervical cancer cell proliferation, invasion, and migration through suppression of its target gene thrombospondin 2." Archives of Gynecology and Obstetrics (2014): 1-8.  WB ;  Human.  
研究领域 肿瘤  心血管  细胞生物  细胞因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human (predicted: Mouse,Rat,Horse)
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 128kDa
细胞定位 细胞外基质 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Thrombospondin 2: 201-300/1172 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.

Function:
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.

Subunit:
Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36. Can bind to fibrinogen, fibronectin, laminin and type V collagen.

Tissue Specificity:
High expression in invertebral disk tissue.

DISEASE:
Genetic variations in THBS2 may be a cause of susceptibility to intervertebral disk disease (IDD) [MIM:603932]; also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain.

Similarity:
Belongs to the thrombospondin family.
Contains 2 EGF-like domains.
Contains 1 laminin G-like domain.
Contains 1 TSP C-terminal (TSPC) domain.
Contains 3 TSP type-1 domains.
Contains 8 TSP type-3 repeats.
Contains 1 VWFC domain.

SWISS:
P35442

Gene ID:
7058

Database links:

Entrez Gene: 7058 Human

Entrez Gene: 21826 Mouse

Entrez Gene: 292406 Rat

Omim: 188061 Human

SwissProt: P35440 Chicken

SwissProt: Q95116 Cow

SwissProt: P35442 Human

SwissProt: Q03350 Mouse

Unigene: 797 Chicken

Unigene: 5522 Cow

Unigene: 371147 Human

Unigene: 26688 Mouse



产品图片
Sample:
MG63(Human) Cell Lysate at 40 ug
Primary: Anti-Thrombospondin 2 (bs-7524R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 128 kD
Observed band size: 128 kD
Sample:
HUVEC(Human) Cell Lysate at 40 ug
Primary: Anti-Thrombospondin 2 (bs-7524R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 128 kD
Observed band size: 128 kD
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