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Rabbit Anti-MSR1  antibody (bs-6763R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-6763R
英文名称 MSR1
中文名称 巨噬细胞清道夫受体1抗体
别    名 CD204; SP-A; CD204 antigen; Macrophage acetylated LDL receptor I and II; Macrophage scavenger receptor 1; Macrophage Scavenger Receptor I; Macrophage scavenger receptor type III; Macrophage scavenger receptor types I and II; Msr 1; MSR1; MSRE_HUMAN; phSR1; phSR2; SCARA 1; SCARA1; Scavenger receptor class A member 1; Scavenger receptor type A; Scvr; SR A; SRA.  
Specific References  (9)     |     bs-6763R has been referenced in 9 publications.
[IF=8.097] Ye M et al. SR-A-Targeted Phase-Transition Nanoparticles for the Detection and Treatment of AtheroscleroticVulnerable Plaques. ACS Appl Mater Interfaces. 2019 Mar 13;11(10):9702-9715.  IHC ;  Mouse.  
[IF=7.666] Ryo Honma. et al. Immunomodulatory Macrophages Enable E-MNC Therapy for Radiation-Induced Salivary Gland Hypofunction. CELLS-BASEL. 2023 Jan;12(10):1417  ICC ;  Mouse.  
[IF=6.832] Yanhong Li. et al. Therapeutic potential of human umbilical cord mesenchymal stem cells on aortic atherosclerotic plaque in a high-fat diet rabbit model. Stem Cell Res Ther. 2021 Dec;12(1):1-14  IHC ;  Rabbit.  
[IF=5.442] Boxing Su. et al. Let-7d inhibits intratumoral macrophage M2 polarization and subsequent tumor angiogenesis by targeting IL-13 and IL-10. 2020 Nov 25  IHC ;  Human.  
[IF=4.784] Zhan Q et al. Structural Characterization and Immunomodulatory Activity of a Novel Acid Polysaccharide Isolated from the Pulp of Rosa laevigata Michx Fruit. Int J Biol Macromol. 2019 Nov 12. pii: S0141-8130(19)37108-9.  Other ;  Mouse.  
[IF=4.307] Mayuko Ichimura-Shimizu. et al. A novel mouse model of non-alcoholic steatohepatitis suggests that liver fibrosis initiates around lipid-laden macrophages. Am J Pathol. 2021 Oct;:  IF ;  Mouse.  
[IF=4.109] Yu Haiyi. et al. The Foam Cell Formation Associated With Imbalanced Cholesterol Homeostasis Due to Airborne Magnetite Nanoparticles Exposure. TOXICOL SCI. 2022 Aug;:  WB ;  Mouse, Human.  
[IF=1.632] Liu Y et al. Isolation and characterization of ovine monocyte-derived macrophages from peripheral blood.(2018)Vet Immunol Immunopathol. Nov;205:83-92.  IF ;  Sheep.  
[IF=0] Yamano et al. Role of deltaNp63(pos) CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas. (2016) Cancer.Sci. 107:123-32  IHC ;  Mouse.  
研究领域 心血管  细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,Mouse,Rat (predicted: Dog,Cow,Horse,Rabbit)
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1ug/Test, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 50kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MSR1/CD204: 211-320/451 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

Function:
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL.

Subunit:
Homotrimer.

Subcellular Location:
Membrane; Single-pass type II membrane protein.

Tissue Specificity:
Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.

DISEASE:
Defects in MSR1 may be a cause of prostate cancer (PC)[MIM:176807]. A malignancy originating in tissues of the prostate.Most prostate cancers are adenocarcinomas that develop in the aciniof the prostatic ducts. Other rare histopathologic types ofprostate cancer that occur in approximately 5% of patients includesmall cell carcinoma, mucinous carcinoma, prostatic ductalcarcinoma, transitional cell carcinoma, squamous cell carcinoma,basal cell carcinoma, adenoid cystic carcinoma (basaloid),signet-ring cell carcinoma and neuroendocrine carcinoma. Note=MSR1variants may play a role in susceptibility to prostate cancer. MSR1variants have been found in individuals with prostate cancer andco-segregate with the disease in some families.
Defects in MSR1 may be a cause of Barrett esophagus (BE)[MIM:614266]. A condition characterized by a metaplastic change inwhich normal esophageal squamous epithelium is replaced by acolumnar and intestinal-type epithelium. Patients with Barrettesophagus have an increased risk of esophageal adenocarcinoma. Themain cause of Barrett esophagus is gastroesophageal reflux. Theretrograde movement of acid and bile salts from the stomach intothe esophagus causes prolonged injury to the esophageal epitheliumand induces chronic esophagitis, which in turn is believed totrigger the pathologic changes. Note=Genetic variants in MSR1 havebeen found in individuals with Barrett esophagus and are thought tocontribute to disease susceptibility.

Similarity:
Contains 1 collagen-like domain.
Contains 1 SRCR domain.

SWISS:
P21757

Gene ID:
4481

Database links:

Entrez Gene: 281311 Cow

Entrez Gene: 4481 Human

Entrez Gene: 498638 Rat

Omim: 153622 Human

SwissProt: P21758 Cow

SwissProt: P21757 Human

Unigene: 147635 Human

Unigene: 231068 Rat



产品图片
Sample: Hela Cell (Human) Lysate at 40 ug
Primary: Anti-MSR1 (bs-6763R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kD
Observed band size: 50 kD
Sample: Bone (Mouse) Lysate at 40 ug
Primary: Anti-MSR1 (bs-6763R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kD
Observed band size: 50 kD
Sample:
Lane 1: Spleen (Mouse) Lysate at 40 ug
Lane 2: Lung (Mouse) Lysate at 40 ug
Lane 3: Liver (Mouse) Lysate at 40 ug
Lane 4: Placenta (Mouse) Lysate at 40 ug
Lane 5: Cerebrum (Mouse) Lysate at 40 ug
Lane 6: Raw264.7 (Mouse) Cell Lysate at 30 ug
Lane 7: NIH/3T3 (Mouse) Cell Lysate at 30 ug
Lane 8: Liver (Rat) Lysate at 40 ug
Lane 9: Cerebrum (Rat) Lysate at 40 ug
Primary: Anti-MSR1 (bs-6763R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50/39 kD
Observed band size: 50 kD
Tissue/cell: human colon carcinoma;4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-MSR1 Polyclonal Antibody, FITC conjugated(bs-6763R-FITC) 1:100, 60 minutes at 37°C. DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei
Tissue/cell: mouse testis tissue;4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-MSR1 Polyclonal Antibody, FITC conjugated(bs-6763R-FITC) 1:100, 60 minutes at 37°C. DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei
Blank control(Blue): U937(fixed with 2% paraformaldehyde (10 min)).
Primary Antibody:Rabbit Anti-MSR1 antibody(bs-6763R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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