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KIF20A Rabbit pAb (bs-7750R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-7750R
英文名称 KIF20A Rabbit pAb
中文名称 KIF20A抗体
别    名 KI20A_HUMAN; Kinesin-like protein KIF20A; MKLP2; RAB6KIFL; RCM6; GG10_2; Mitotic kinesin-like protein 2(MKlp2); Rab6-interacting kinesin-like protein; Rabkinesin-6; kinesin family member 20A;  
Specific References  (1)     |     bs-7750R has been referenced in 1 publications.
[IF=4.848] Jie Jiang. et al. Identification of Hub Genes Associated With Melanoma Development by Comprehensive Bioinformatics Analysis. Front Oncol. 2021; 11: 621430  IHC ;  Human.  
研究领域 细胞生物  信号转导  细胞分化  细胞外基质  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human,Mouse,Rat,Rabbit)
产品应用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 100 kDa
检测分子量
细胞定位 细胞浆 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KIF20A: 353-450/890 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; intercellular bridge; and midbody. Implicated in restrictive cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]

Function:
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.

Subcellular Location:
Golgi apparatus (By similarity). Cytoplasm, cytoskeleton, spindle.

Post-translational modifications:
Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.

Similarity:
Belongs to the kinesin-like protein family.
Contains 1 kinesin-motor domain.

SWISS:
O95235

Gene ID:
10112

Database links:

Entrez Gene: 527854 Cow

Entrez Gene: 10112 Human

Entrez Gene: 19348 Mouse

Entrez Gene: 361308 Rat

SwissProt: Q29RT6 Cow

SwissProt: O95235 Human

SwissProt: P97329 Mouse



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