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Rabbit Anti-BMPER  antibody (bs-6910R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-6910R
英文名称 BMPER
中文名称 BMP内皮细胞调节蛋白抗体
别    名 BMP binding endothelial regulator; BMP binding endothelial regulator precursor protein; Bone morphogenetic protein binding endothelial cell precursor derived regulator; CRIM3; Crossveinless 2; CV 2; CV2; hCV2; Protein crossveinless 2; BMPER_HUMAN.  
研究领域 心血管  细胞生物  免疫学  信号转导  干细胞  生长因子和激素  细胞周期蛋白  转录调节因子  内皮细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,Mouse,Rat (predicted: Dog,Pig,Cow,Rabbit)
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 72kDa
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BMPER: 501-600/686 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011].
BMPER is a BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity. It may also regulate BMP responsiveness in osteoblasts and chondrocytes.

Subunit:
Interacts with BMP4.

Subcellular Location:
Secreted.

Tissue Specificity:
Highly expressed in lung, and brain and also in primary chondrocytes.

Similarity:
Contains 1 TIL (trypsin inhibitory-like) domain. Contains 5 VWFC domains. Contains 1 VWFD domain.

SWISS:
Q8N8U9

Gene ID:
168667

Database links:

Entrez Gene: 168667 Human

Entrez Gene: 73230 Mouse

Entrez Gene: 300455 Rat

Omim: 608699 Human

SwissProt: Q8N8U9 Human

SwissProt: Q8CJ69 Mouse

Unigene: 660998 Human

Unigene: 735847 Human

Unigene: 335020 Mouse



产品图片
Sample: HepG2 Cell (Human) Lysate at 30 ug
Primary: Anti-BMPER (bs-6910R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 72kD
Observed band size: 75kD
Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (BMPER) Polyclonal Antibody, Unconjugated (bs-6910R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (BMPER) Polyclonal Antibody, Unconjugated (bs-6910R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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