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Rabbit Anti-UNC5B antibody (bs-11492R)
~~~促销,代码KT001~~~
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说明书: 100ul  200ul
100ul/1680.00元
200ul/2480.00元
大包装/询价

产品编号 bs-11492R
英文名称 UNC5B
中文名称 神经突起诱导因子受体UNC5B抗体
别    名 UNC5H2; Netrin receptor UNC5B; Netrin receptor UNC5B Precursor; p53 regulated receptor for death and life; p53 regulated receptor for death and life protein 1; p53-regulated receptor for death and life protein 1; p53RDL1; Protein unc-5 homolog 2; Protein unc-5 homolog B; Protein XUNC 5; Transmembrane receptor Unc5H2; Unc 5 homolog 2; Unc 5 homolog B; UNC 5B; Unc5 (C.elegans homolog) b; Unc5b; UNC5B_HUMAN; UNC5H2.  
Specific References  (1)     |     bs-11492R has been referenced in 1 publications.
[IF=1.49] Ko CL et al. Netrin-1 Dampens Hypobaric Hypoxia-Induced Lung Injury in Mice. High Alt Med Biol. 2019 Jul 22.   IHF ;  Mouse.  
研究领域 心血管  细胞生物  神经生物学  血管内皮细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,  (predicted: Dog, Pig, Horse, Rabbit, )
产品应用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 101kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human UNC5B:188-260/945 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Function:
FunctionReceptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.

Subunit:
Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part. Interacts (via death domain) with DAPK1 (via death domain).

Subcellular Location:
Membrane; Single-pass type I membrane protein. Note=Associated with lipid raft.

Tissue Specificity:
Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.

Post-translational modifications:
Phosphorylated on cytoplasmic tyrosine residues (By similarity).
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
Palmitoylation target the protein to the lipid rafts, and is required for pro-apoptotic activity.

Similarity:
Belongs to the unc-5 family.
Contains 1 death domain.
Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 2 TSP type-1 domains.
Contains 1 ZU5 domain.

SWISS:
Q8IZJ1

Gene ID:
219699

Database links:

Entrez Gene: 219699 Human

Entrez Gene: 107449 Mouse

Omim: 607870 Human

SwissProt: Q8IZJ1 Human

SwissProt: Q8K1S3 Mouse

Unigene: 522997 Human

Unigene: 290433 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片
Sample:
U87MG(Human) Cell Lysate at 30 ug
HT1080(Human) Cell Lysate at 30 ug
Cerebrum (Mouse) Lysate at 40 ug
Cerebrum (Rat) Lysate at 40 ug
Primary: Anti- UNC5B (bs-11492R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 101 kD
Observed band size: 111 kD
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