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TWSG1 Rabbit pAb (bs-11606R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-11606R
英文名称 TWSG1 Rabbit pAb
中文名称 扭转原肠胚形成同源蛋白1抗体
别    名 PSEC0250; TSG; TSG1; twisted gastrulation homolog 1; Twisted gastrulation protein; TWSG1_HUMAN.  
Specific References  (1)     |     bs-11606R has been referenced in 1 publications.
[IF=1.394] Liu Zhuohang. et al. Twisted gastrulation signaling modulator 1 promotes the ability of glioma cell through activating Akt pathway. Neuroreport. 2021 Feb;32(3):198-205  IHC ;  Human.  
研究领域 细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog)
产品应用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 22 kDa
检测分子量
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TWSG1: 151-223/223 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Twisted Gastrulation Protein 1(TWSG1) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins thereby preventing BMPs from binding to their receptors. It can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex.

Function:
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development

Subunit:
nteracts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7

Subcellular Location:
Secreted

Similarity:
Belongs to the twisted gastrulation protein family.

SWISS:
Q9GZX9

Gene ID:
57045

Database links:

Entrez Gene: 57045 Human

Entrez Gene: 705804 Rhesus monkey

Omim: 605049 Human

SwissProt: Q9GZX9 Human

Unigene: 514685 Human




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