| 产品编号 | bs-10036R |
| 英文名称 | REG4 |
| 中文名称 | 再生基因蛋白4抗体 |
| 别 名 | Gastrointestinal secretory protein; GISP; REG IV; REG like protein; Regenerating gene type IV; Regenerating islet derived family member 4; Regenerating islet derived protein 4 precursor; REGIV; RELP; REG4_HUMAN. |
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Specific References (2) | bs-10036R has been referenced in 2 publications.
[IF=5.13] Nishimura R et al. Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids. J Gastroenterol. 2019 Jul;54(7):608-620. 3D IHC ; Human.
[IF=2.489] Dandan Chai. et al. CDX2 and Reg IV expression and correlation in gastric cancer. Bmc Gastroenterol. 2021 Dec;21(1):1-12 IHC ; Human.
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| 研究领域 | 肿瘤 细胞生物 染色质和核信号 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Mouse,Rat,Dog,Pig,Cow) |
| 产品应用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 18kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human REG4: 71-158/158 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
Reg IV is part of the regenerating gene family within the C-type lectin superfamily. This family is involved in liver, pancreatic, gastric and intestinal cell proliferation and differentiation. Reg IV is a 158-amino acid secretory protein implicated in cell regeneration and/or survival with a definite growth stimulating effect on pancreatic beta cells. It is highly expressed in colorectal, gastric, prostate and other types of cancer. Reg IV-positive tumor cells display different phenotypes including mucus-secreting, enterocyte-like, and undifferentiated. Function: May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. Subcellular Location: Secreted. Tissue Specificity: Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells. Similarity: Contains 1 C-type lectin domain. SWISS: Q9BYZ8 Gene ID: 83998 Database links: Entrez Gene: 83998 Human Omim: 609846 Human SwissProt: Q9BYZ8 Human Unigene: 660883 Human |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
