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Rabbit Anti-TMEM106B antibody (bs-11694R)
~~~促销,代码KT2401~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-11694R
英文名称 TMEM106B
中文名称 跨膜蛋白106B抗体
别    名 Tmem106b; Transmembrane protein 106B; 2310036D22Rik; 5830455K21Rik; 6430519M21Rik; AI428776; AI661344; FLJ11273; LRRGT00101; MGC33727; MGC94135; T106B_HUMAN.  
Specific References  (2)     |     bs-11694R has been referenced in 2 publications.
[IF=41.582] Andrew Chang. et al. Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell. 2022 Mar;:  WB ;  Human.  
[IF=4.39] Satoh, Jun-ichi, et al. "TMEM106B expression is reduced in Alzheimers disease brains." Alzheimers Research & Therapy 6.2 (2014): 17.  WB ;  Human.  
研究领域 细胞生物  神经生物学  细胞膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用 WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 31kDa
细胞定位 细胞浆 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TMEM106B: 101-200/274 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 TMEM106B is a 274 amino acid single-pass membrane protein that is encoded by a gene which maps to human chromosome 7. Chromosome 7 houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders, including cases of acute myelogenous leukemia and myelodysplasia.

Subcellular Location:
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein.

Tissue Specificity:
Expressed in frontal cortex.

DISEASE:
Note=TMEM106B genotype, when containing 3 particular single-nucleotide polymorphisms, is strongly correlated with frontotemporal lobar degeneration with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia and 20% of patients with this neurodegenerative disease have autosomal dominant GRN mutations. Expression of TMEM106B associated with these polymorphisms is increased in frontal cortex of patients with FTLD-TDP compared to unaffected controls. Thus, increased TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression.

Similarity:
Belongs to the TMEM106 family.

SWISS:
Q9NUM4

Gene ID:
54664

Database links:

Entrez Gene: 54664 Human

Entrez Gene: 71900 Mouse

Entrez Gene: 312132 Rat

Omim: 613413 Human

SwissProt: Q9NUM4 Human

SwissProt: Q80X71 Mouse

SwissProt: Q6AYA5 Rat

Unigene: 396358 Human



产品图片
Sample:
Lane 1: Recombinant human TMEM106B protein, N-Trx-His(bs-42250P)
Primary: Anti-TMEM106B (bs-11694R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kDa
Observed band size: 32 kDa
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