| 产品编号 | bs-11740R |
| 英文名称 | EBF2 Rabbit pAb |
| 中文名称 | 早期B淋巴细胞因子2抗体 |
| 别 名 | COE 2; COE2; Collier Olf and EBF 2; Early B cell factor 2; EBF 2; FLJ11500; Metencephalon mesencephalnon olfactory transcription factor 1; O/E 3; O/E3; OE 3; OE3; OLF 1/EBF like 3; Transcription factor COE2; COE2_HUMAN. |
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Specific References (2) | bs-11740R has been referenced in 2 publications.
[IF=14.919] Chen, Yan-Ting. et al. Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance. Nat Commun. 2021 Nov;12(1):1-18 FC ; Mouse.
[IF=6.78] Andrea Estefanía Portales. et al. CDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue. LIFE SCI. 2023 Jun;322:121652 FC ; Mouse.
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| 研究领域 | 细胞生物 神经生物学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 产品应用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 63 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞核 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EBF2: 331-400/575 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
Early B-cell factor 2 is a 575 amino acid protein belonging to the COE family of proteins, whose members are all helix-loop-helix transcription factors. EBF2 is a transcription factor which, in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, activates the decoy receptor for RANKL, OPG, in osteoblasts. OPG, in turn, regulates osteoclast differentiation. Lack of EBF2 has been found to cause a small defect in the terminal differentiation of osteoblasts, along with reduced bone mass and an increase in osteoclasts. Localized to the nucleus, EBF2 forms a homodimer or a heterodimer with a related family member. Function: EBF2 (Early B-cell factor 2) belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors. In osteoblasts it activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. EBF2 acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. It recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Subunit: Forms either a homodimer or a heterodimer with a relatedfamily member Subcellular Location: Nuclear Similarity: Belongs to the COE family. Contains 1 IPT/TIG domain. SWISS: Q9HAK2 Gene ID: 64641 Database links: Entrez Gene: 64641 Human Entrez Gene: 13592 Mouse Entrez Gene: 373696 Xenopus laevis Entrez Gene: 394808 Xenopus tropicalis Omim: 609934 Human SwissProt: Q9HAK2 Human SwissProt: O08792 Mouse SwissProt: B7ZRI2 Xenopus laevis SwissProt: O73741 Xenopus laevis SwissProt: Q6P4K7 Xenopus tropicalis |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
