| 产品编号 | bs-10938R |
| 英文名称 | D3R |
| 中文名称 | 凋亡诱导受体TNFRSF25抗体 |
| 别 名 | Apo 3; Apo-3; Apo3; Apoptosis inducing receptor AIR; Apoptosis inducing receptor; Apoptosis mediating receptor; Apoptosis mediating receptor DR 3; Apoptosis mediating receptor DR3; Apoptosis mediating receptor TRAMP; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; DDR 3; DDR3; Death domain receptor 3; Death Receptor 3; Death receptor beta; DR 3; LARD; Lymphocyte associated receptor of death; Lymphocyte-associated receptor of death; Protein WSL; Protein WSL-1; TNFRSF 12; TNFRSF 25; TNFRSF12; TNFRSF25; TNR25_HUMAN; TR 3; TR3; TRAMP; Translocating chain association membrane protein; Tumor necrosis factor receptor superfamily member 12; Tumor necrosis factor receptor superfamily member 25; WSL 1; WSL; WSL LR; WSL protein; WSL1; WSL1 protein; WSLLR. |
| 研究领域 | 神经生物学 信号转导 细胞凋亡 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 43kDa |
| 细胞定位 | 细胞膜 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TNFRSF25: 25-100/417 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor is expressed preferentiallyin the tissues enriched in lymphocytes, and it may play a role inregulating lymphocyte homeostasis. This receptor has been shown tostimulate NF-kappa B activity and regulate cell apoptosis. Thesignal transduction of this receptor is mediated by various deathdomain containing adaptor proteins. Knockout studies in micesuggested the role of this gene in the removal of self-reactive Tcells in the thymus. Multiple alternatively spliced transcriptvariants of this gene encoding distinct isoforms have beenreported, most of which are potentially secreted molecules. Thealternative splicing of this gene in B and T cells encounters aprogrammed change upon T-cell activation, which predominantlyproduces full-length, membrane bound isoforms, and is thought to beinvolved in controlling lymphocyte proliferation induced by T-cellactivation. [provided by RefSeq, Jul 2008]. Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directlywith the adapter TRADD. Mediates activation of NF-kappa-B andinduces apoptosis. May play a role in regulating lymphocytehomeostasis. Subunit: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signalingcascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4. Subcellular Location: Isoform 1, 2, 9, 11: Cell membrane; Single-pass type I membrane protein. Isoform 3, 4, 6, 7, 8, 10, 12:Secreted. Tissue Specificity: Abundantly expressed in thymocytes andlymphocytes. Detected in lymphocyte-rich tissues such as thymus,colon, intestine, and spleen. Also found in the prostate. Post-translational modifications: Glycosylated (Probable). Similarity: Contains 1 death domain. Contains 4 TNFR-Cys repeats. SWISS: Q93038 Gene ID: 8718 Database links: Entrez Gene: 8718 Human Entrez Gene: 85030 Mouse Omim: 603366 Human SwissProt: Q93038 Human Unigene: 462529 Human Unigene: 101198 Mou |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
