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Rabbit Anti-ZIC5  antibody (bs-12147R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-12147R
英文名称 ZIC5
中文名称 锌指蛋白ZIC5抗体
别    名 zic5; ZIC5_HUMAN; Zinc finger protein of the cerebellum 5; Zinc finger protein ZIC 5.  
Specific References  (2)     |     bs-12147R has been referenced in 2 publications.
[IF=7.109] Tan, Yi-Fan. et al. AR-regulated ZIC5 contributes to the aggressiveness of prostate cancer. CELL DEATH DISCOV. 2022 Sep;8(1):1-15  IHC, WB ;  Human.  
[IF=2.456] Han W et al. Clinicopathologic and Prognostic Significance of the Zinc Finger of the Cerebellum Family in Invasive Breast Cancer.J Breast Cancer. 2018 Mar;21(1):51-61.  IHC ;  Human.  
研究领域 细胞生物  神经生物学  信号转导  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse (predicted: Sheep,Horse,Cow,Dog,Rat,Human)
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 68kDa
细胞定位 细胞核 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZIC5: 501-600/663 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Zic5 (zinc finger protein of the cerebellum 5) is a C2H2 zinc finger transcription factor that influences development of the neural crest. Zic family members are abundant in developing and adult cerebellum. Zic family members are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. Zic5 is closely linked to Zic2, a related family member on chromosome 13.

Function:
Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the GLI C2H2-type zinc-finger protein family.
Contains 4 C2H2-type zinc fingers.

SWISS:
Q96T25

Gene ID:
85416

Database links:

Entrez Gene: 85416 Human

Entrez Gene: 65100 Mouse

Entrez Gene: 361095 Rat

SwissProt: Q96T25 Human

SwissProt: Q7TQ40 Mouse

Unigene: 508570 Human

Unigene: 390761 Mouse

Unigene: 198356 Rat



产品图片
Paraformaldehyde-fixed, paraffin embedded (mouse skin); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (ZIC5) Polyclonal Antibody, Unconjugated (bs-12147R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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