| 产品编号 | bs-12862R |
| 英文名称 | beta subunit Cholera Toxin |
| 中文名称 | 霍乱肠毒素β链抗体 |
| 别 名 | Cholera Toxin beta; beta subunit Cholera Toxin; Cholera enterotoxin B chain; Cholera enterotoxin beta chain; Cholera enterotoxin gamma chain; Cholera enterotoxin subunit B; Cholera toxin B protein; Choleragenoid; CTX B; CTXB; TOX B; TOXB; VC1456; CHTB_VIBCH. |
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Specific References (2) | bs-12862R has been referenced in 2 publications.
[IF=14.919] Zhao, Yuanyuan. et al. ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer’s disease models. Nat Commun. 2022 Mar;13(1):1-20 IF ; Mouse.
[IF=1.54] Tanaka, Koichi, et al. "Possible role of the myelinated neural network in the parietal peritoneum in rats as a mechanoreceptor." The Anatomical Record (2017). IHC-F ; Rat.
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| 研究领域 | 细菌及病毒 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Cholera Toxin) |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 12kDa |
| 细胞定位 | 细胞膜 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from CTXB/beta subunit Cholera Toxin: 51-124/124 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The B subunit of cholera toxin (CtxB) binds to a GM1-ganglioside receptor, a ubiquitous glycolipid cell surface receptor. This binding is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin A subunit into cells. The beta chain has no toxic activity by itself. The holotoxin consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge. The A subunit (and Cholera toxin) activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP. Function: The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself. Subunit: The holotoxin (choleragen) consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge. Subcellular Location: Secreted. Host cell membrane (Potential). SWISS: P01556 Gene ID: 57740119 Database links:
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
