| 产品编号 | bs-14494R |
| 英文名称 | EBNA 3C |
| 中文名称 | EB病毒核抗原-3C抗体 |
| 别 名 | EBNA3C; EBNA 4B; EBNA 6; EBNA 3C; EBNA6_EBVB9; EBV; EBV nuclear antigen 6; Epstein Barr nuclear antigen 6; HHV4; Human Herpesvirus 4. |
| 研究领域 | 免疫学 细菌及病毒 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human Herpesvirus 4) |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 109kDa |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EBNA 3C: 901-992/992 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
EBNA 3C is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines and is essential for EBV mediated transformation of these cell lines. This viral nuclear protein is essential for EBV mediated positive immunoblastic lymphomas, and functions as a transcription factor. Function: Plays an essential role for the activation and mmortalization of human B-cells. Represses transcription of viral romoters TP1 and Cp through interaction with host RBPJ, and nhibits EBNA2-mediated activation of these promoters. Since Cp is he promoter for all EBNA mRNAs, EBNA6 probably contributes to a egative autoregulatory control loop. Alternatively, EBNA6 also egulates the transcription of the EBV oncogene LMP1 in a cell ycle-dependent manner. It modulates the activity of several host roteins involved in cell cycle regulation including host cyclin A, YC, RB and p27 mainly through binding to the host SCF(SKP2) omplex. Subunit: Interacts with host CTPB1; this interaction seems mportant for EBNA6-mediated transcriptional repression. Interacts ith host MYC; this interaction enhances MYC stability. Interacts via N-terminus) with host RBPJ. Subcellular Location: Host nucleus matrix. Note=Associated with he nuclear matrix. Similarity: Belongs to the herpesviridae EBNA-6 family. SWISS: P03204 Gene ID: 3783763 Database links: Entrez Gene: 3783763 Human SwissProt: P03204 human
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
