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Rabbit Anti-KMT2C  antibody (bs-16792R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-16792R
英文名称 KMT2C
中文名称 组蛋白赖氨酸N-甲基转移酶2C抗体
别    名 Histone-lysine N-methyltransferase MLL3; Homologous to ALR protein; KMT2C; Lysine N-methyltransferase 2C; MLL3; KMT2C_HUMAN; Myeloid/lymphoid or mixed-lineage leukemia protein 3; Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog.  
研究领域 肿瘤  免疫学  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse (predicted: Human,Rat,Pig)
产品应用 IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 541kDa
细胞定位 细胞核 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KMT2C: 4701-4800/4911 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]

Function:
Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/MLL3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.

Similarity:
Belongs to the histone-lysine methyltransferase family.
TRX/MLL subfamily.
Contains 1 A.T hook DNA-binding domain.
Contains 1 DHHC-type zinc finger.
Contains 6 PHD-type zinc fingers.
Contains 1 post-SET domain.
Contains 1 RING-type zinc finger.
Contains 1 SET domain.

SWISS:
Q8NEZ4

Gene ID:
58508

Database links:

Entrez Gene: 58508 Human

Omim: 606833 Human

SwissProt: Q8NEZ4 Human

Unigene: 647120 Human



产品图片
Paraformaldehyde-fixed, paraffin embedded (mouse testis tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (KMT2C) Polyclonal Antibody, Unconjugated (bs-16792R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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