| 产品编号 | bs-17662R |
| 英文名称 | SPHKAP |
| 中文名称 | 鞘氨醇激酶1相互作用蛋白抗体 |
| 别 名 | A-kinase anchor protein SPHKAP; DKFZp781H143; DKFZp781J171; KIAA1678; MGC132614; MGC132616; SKIP; Sphingosine kinase type 1-interacting protein; SPHK1 (sphingosine kinase type 1) interacting protein; SPHK1 interactor, AKAP domain containing; ; SPHK1-interacting protein; SPHK1-interactor and AKAP domain-containing protein; sphkap; SPKAP_HUMAN. |
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Specific References (1) | bs-17662R has been referenced in 1 publications.
[IF=4.183] Zhu Y et al. Protein Expression Profile in Rat Silicosis Model Reveals Upregulation of PTPN2 and Its Inhibitory Effect on Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3. Int J Mol Sci. 2020 Feb 11;21(4). WB ; Rat&Mouse.
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| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 186kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPHKAP: 1131-1230/1700 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. Subunit: Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. Subcellular Location: Cytoplasm. Colocalizes with SPHK1 in the cytoplasm. Tissue Specificity: Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain. Similarity: Belongs to the AKAP110 family. SWISS: Q2M3C7 Gene ID: 80309 Database links: Entrez Gene: 80309 Human Entrez Gene: 77629 Mouse Omim: 611646 Human SwissProt: Q2M3C7 Human SwissProt: Q6NSW3 Mouse Unigene: 436306 Human Unigene: 154303 Mouse |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
