| 产品编号 | bs-18686R |
| 英文名称 | MASS1/GPR98 |
| 中文名称 | G蛋白偶联受体98抗体 |
| 别 名 | DKFZp761P0710; FEB 4; FEB4; G protein coupled receptor 98; G-protein coupled receptor 98; GPR 98; GPR98; GPR98_HUMAN; KIAA0686; MASS 1; Monogenic audiogenic seizure susceptibility 1 homolog; Monogenic audiogenic seizure susceptibility protein 1 homolog; USH 2B; USH 2C; USH2B; USH2C; Usher syndrome 2C; Usher syndrome type 2C protein; Usher syndrome type-2C protein; Very large G protein coupled receptor; Very large G protein coupled receptor 1; Very large G-protein coupled receptor 1; VLGR 1; VLGR 1b; VLGR1; VLGR1b. |
| 研究领域 | 细胞生物 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Mouse,Rat,Cow,Horse,Sheep) |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 693kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MASS1/GPR98: 2451-2550/6306 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
MASS1 (for monogenic audiogenic seizure susceptibility 1) is one of the largest known GPCRs and is therefore referred to as Very Large G protein-coupled receptor 1 (VLGR1) (1,2). MASS1 is a large, calcium-binding GPCR expressed in the central nervous system and the eye (2,3). MASS1 has a large ectodomain containing multiple calcium exchanger beta repeats that resemble regulatory domains of sodium-calcium exchanger proteins (3). The human MASS1 gene maps to chromosome 5q14 and encodes a 1967 amino acid protein (1,2,4). The MASS1 gene has been linked to the autosomal recessive inheritance of general epilepsy in Frings mice that have seizures in response to loud noises (5). Function: Receptor that may have an important role in the development of the central nervous system. Subcellular Location: Cell membrane. Tissue Specificity: Expressed at low levels in adult tissues. DISEASE: Defects in GPR98 are the cause of Usher syndrome type 2C (USH2C) [MIM:605472]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses. Defects in GPR98 may be a cause of familial febrile convulsions type 4 (FEB4) [MIM:604352]; also known as familial febrile seizures 4. Febrile convulsions are seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily . Contains 35 Calx-beta domains. Contains 6 EAR repeats. Contains 1 GPS domain. SWISS: Q8WXG9 Gene ID: 84059 Database links: Entrez Gene: 101837835 Hamster Entrez Gene: 100073239 Horse Entrez Gene: 84059 Human Omim: 602851 Human SwissProt: Q8WXG9 Human Unigene: 591777 Human |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
