| 产品编号 | bs-20893R |
| 英文名称 | Tristetraprolin/ZFP36 |
| 中文名称 | Tristetraprolin抗体 |
| 别 名 | G0/G1 switch regulatory protein 24; G0S24; Growth factor-inducible nuclear protein NUP475; NUP475; Protein TIS11A; RNF162A; TIS 11; TIS11; TIS11A; Tristetraprolin; Tristetraproline; TTP; TTP_HUMAN; Zfp-36; ZFP36; Zinc finger protein 36; Zinc finger protein 36 homolog; Zinc finger protein 36, C3H type, homolog (mouse); Zinc finger protein, C3H type, 36 homolog. |
| 研究领域 | 免疫学 染色质和核信号 神经生物学 信号转导 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Mouse,Rat) |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 35kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Tristetraprolin: 101-200/319 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
ZFP36 (ZFP36 Ring Finger Protein) is a Protein Coding gene. Among its related pathways are Spinal Cord Injury and ErbB1 downstream signaling. GO annotations related to this gene include poly(A) RNA binding and enzyme binding. An important paralog of this gene is ZFP36L2. Function: mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Subunit: Interacts (via C-terminus) with CNOT1. Subcellular Location: Nucleus {ECO:0000269|PubMed:15014438}. Cytoplasm {ECO:0000269|PubMed:15014438}. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules. Post-translational modifications: Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation. Similarity: Contains 2 C3H1-type zinc fingers. SWISS: P26651 Gene ID: 7538 Database links: Entrez Gene: 7538 Human Omim: 190700 Human SwissProt: P26651 Human Unigene: 534052 Human Unigene: 728064 Human Unigene: 82737 Rat |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
