产品编号 | bsm-33263M |
英文名称 | PPAR delta |
中文名称 | D型-过氧化酶活化增生受体单克隆抗体 |
别 名 | FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated receptor beta (PPAR-beta); Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR beta; PPAR-beta; PPAR-delta; PPAR-? PPARB; PPARD; PPARD_HUMAN. |
Specific References (1) | bsm-33263M has been referenced in 1 publications.
[IF=4.248] Lv Xiaoting. et al. αCGRP deficiency aggravates pulmonary fibrosis by activating the PPARγ signaling pathway. GENES IMMUN. 2023 May;:1-10 IHC,IF ; Rat,Mouse,Human.
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研究领域 | 心血管 免疫学 |
抗体来源 | Mouse |
克隆类型 | Monoclonal |
克 隆 号 | 4H10 |
交叉反应 | (predicted: Human,Mouse,Rat) |
产品应用 | WB=1:500-2000, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理论分子量 | 48kDa |
细胞定位 | 细胞核 |
性 状 | Liquid |
浓 度 | 1mg/ml |
免 疫 原 | Recombinant human PPAR delta Protein |
亚 型 | IgG |
纯化方法 | affinity purified by Protein G |
缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
产品介绍 |
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain. Function: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous with maximal levels in placenta and skeletal muscle. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: Q03181 Gene ID: 5467 Database links: Entrez Gene: 5467 Human Entrez Gene: 19015 Mouse Omim: 600409 Human SwissProt: Q03181 Human SwissProt: P35396 Mouse Unigene: 696032 Human Unigene: 328914 Mouse Unigene: 96181 Rat 类固醇受体(Steroid Receptors) 研究人员指出该分子的功能,极可能就是阻断心血管免疫发炎反应的讯号传递过程。PPAR-delta基因是控制肌肉发展的重要基因,在增加老鼠耐力的同时还能帮助它燃烧掉脂肪,研究人员发现,对于与新陈代谢有关的各项疾病,从心脏病到肥胖症都有启发性的意义,他可以阻止脂肪沉淀在动脉壁上,进而防止动脉硬化症的发生,该蛋白参与脂肪代谢、肥胖、糖尿病、动脉硬化和癌症的发病。 在动脉硬化现象发生的早期,免疫细胞会促使血管慢性的发炎,因而造成血管不断地吸收和输送脂肪,进而导致脂肪的堆积与血管硬化,而PPAR-delta就像警卫分子一样,时时降低发炎反应和抑制动脉硬化斑的形成,因此该分子应该是相关药物研发,相当值得切入的目标。 研究人员认为,这个发现将给药厂研发治疗心血管疾病的新药提供新的线索。 |
1、抗体溶解方法 | |
2、抗体修复方式 | |
3、常用试剂的配制 | |
4、免疫组化操作步骤 | |
5、免疫组化问题解答 | |
6、Western Blotting 操作步骤 | |
7、Western Blotting 问题解答 | |
8、关于肽链的设计 | |
9、多肽的溶解与保存 | |
10、酶标抗体效价测定程序 | |