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Rabbit Anti-Wnt3a  antibody (bs-23278R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-23278R
英文名称 Wnt3a
中文名称 信号通路Wnt3a抗体
别    名 MGC119418; MGC119419; MGC119420; Protein Wnt 3a Precursor; Protein Wnt-3a; Wingless type MMTV integration site family member 3A; Wnt 3a; WNT3A protein.  
Specific References  (3)     |     bs-23278R has been referenced in 3 publications.
[IF=5.895] Yu-Sheng Shi. et al. Pteris laeta Wall. and Its New Phytochemical, Pterosinsade A, Promote Hippocampal Neurogenesis via Activating the Wnt Signaling Pathway. J AGR FOOD CHEM. 2023;XXXX(XXX):XXX-XXX  WB ;  Murine.  
[IF=2.534] EnShuang Xu. et al. Establishment and transcriptome characterization of tamoxifen-resistant canine mammary gland tumor cells. Res Vet Sci. 2022 Feb;:  WB ;  Dog.  
[IF=0] Liyi Huang. et al. Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice. MedComm. 2022 Aug;3(3):e160  WB ;  Mouse.  
研究领域 细胞生物  神经生物学  干细胞  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Rat (predicted: Human,Mouse,Dog,Pig,Cow,Rabbit,Sheep)
产品应用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 37kDa
细胞定位 细胞外基质 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Wnt3a: 135-230/352 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]

Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.

Subunit:
Interacts with PORCN. Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.

Subcellular Location:
Secreted, extracellular space, extracellular matr

Tissue Specificity:
Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.

Post-translational modifications:
Palmitoylation at Ser-209 by PORCN is required for proper trafficking to cell surface, vacuolar acidification is critical to release palmitoylated WNT3A from WLS in secretory vesicles.

Similarity:
Belongs to the Wnt family.

SWISS:
P56704

Gene ID:
89780

Database links:

Entrez Gene: 89780 Human

Entrez Gene: 22416 Mouse

Entrez Gene: 303181 Rat

Omim: 606359 Human

SwissProt: P56704 Human

SwissProt: P27467 Mouse

Unigene: 336930 Human

Unigene: 1367 Mouse

Unigene: 130971 Rat



Wnt3a是Wnt家族的成员之一,对神经干细胞的增殖及分化有一定的调控作用,Wnt3a蛋白可以促进神经干细胞向神经元分化.
产品图片
Sample:
Lane 1: Cerebrum (Rat) Lysate at 40 ug
Lane 2: Stomach (Rat) Lysate at 40 ug
Primary: Anti-Wnt3a (bs-23278R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 39 kD
Observed band size: 39 kD
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