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Rabbit Anti-Arginase 1  antibody (bs-23837R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-23837R
英文名称 Arginase 1
中文名称 精氨酸酶1抗体
别    名 liver Arginase; ARG 1; ARG1; ARGI1_HUMAN; Arginase1; Arginase liver; Arginase type I; Arginase I; ArginaseI; Arginase-1; Arginase1; Liver type arginase; Liver-type arginase; Type I arginase.  
Specific References  (1)     |     bs-23837R has been referenced in 1 publications.
[IF=10.435] Li, Kanglu. et al. Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages. J Nanobiotechnol. 2022 Dec;20(1):1-20  IHC ;  Rat.  
研究领域 肿瘤  细胞生物  免疫学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,Rat (predicted: Mouse,Dog,Pig,Rabbit)
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 35kDa
细胞定位 细胞浆 
性    状 Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Arginase 1 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Arginase I which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea . The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. The human arginase II gene, which maps to chromosome 14q24.1-q24.3, encodes a 354 amino acid protein. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence.

Subunit:
Homotrimer.

Subcellular Location:
Cytoplasm.

DISEASE:
Defects in ARG1 are the cause of argininemia (ARGIN) ; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.

Similarity:
Belongs to the arginase family.

SWISS:
P05089

Gene ID:
383

Database links:

Entrez Gene: 513608 Cow

Entrez Gene: 383 Human

Entrez Gene: 11846 Mouse

Entrez Gene: 397115 Pig

Entrez Gene: 100008814 Rabbit

Entrez Gene: 29221 Rat

Omim: 608313 Human

SwissProt: Q2KJ64 Cow

SwissProt: P05089 Human

SwissProt: Q61176 Mouse

SwissProt: Q95JC8 Pig

SwissProt: Q95KM0 Rabbit

SwissProt: P07824 Rat

Unigene: 440934 Human

Unigene: 154144 Mouse

Unigene: 9857 Rat



产品图片
Sample:
Liver(Rat) Lysate at 40 ug
Primary: Anti-Arginase 1 (bs-23837R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 35 kD
Observed band size: 34 kD
Sample:
HepG2(Human) Cell Lysate at 30 ug
Primary: Anti-Arginase 1 (bs-23837R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 35 kD
Observed band size: 34 kD
Paraformaldehyde-fixed, paraffin embedded (Rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Arginase 1) Polyclonal Antibody, Unconjugated (bs-23837R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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