| 产品编号 | bs-10496R |
| 英文名称 | FBH1 |
| 中文名称 | F-box蛋白家族FBXO18抗体 |
| 别 名 | Fbx18; FLJ14590; MGC131916; MGC141935; MGC141937; F box DNA helicase 1; F box only protein 18; F box protein, helicase, 18; F-box only protein 18, F-box DNA helicase 1; FBX18_HUMAN. |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Mouse,Rat,Horse,Rabbit) |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 118kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Liquid |
| 浓 度 | 1mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FBXO18 : 1-100/1043 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
FBXO18 belongs to the F-box protein family, whose members share the F-box, an approximately 40 amino acid motif. It has both DNA-dependent ATPase and DNA unwinding activities. FBXO18 is a 1,043 amino acid protein encoded by the human gene FBXO18. FBXO18 belongs to the helicase family (UvrD subfamily) and contains one F-box domain. This nuclear protein is a DNA-dependent ATPase that unwinds double-stranded DNA in a 3' to 5' direction. FBXO18 also recognizes and binds to a variety of phosphorylated proteins and promotes their ubiquitination and degradation. It also interacts with Skp1 in the SCF E3 ubiquitin ligase complex consisting of Skp1, CUL-1, Rbx1 and FBXO18. Function: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Subunit: Part of a SCF E3 ubiquitin ligase complex consisting of SKP1, CUL1, RBX1 and FBXO18. Interacts with SKP1. Subcellular Location: Nuclear Similarity: Belongs to the helicase family. UvrD subfamily. Contains 1 F-box domain. SWISS: Q8NFZ0 Gene ID: 84893 Database links: Entrez Gene: 84893 Human GenBank: BC113377 Human Omim: 607222 Human SwissProt: Q8NFZ0 Human Unigene: 498543 Human |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
