| 产品编号 | bs-21907R |
| 英文名称 | DLL1 |
| 中文名称 | Notch信号通路Delta样配体1抗体 |
| 别 名 | Delta (Drosophila) like 1; Delta; Delta like 1 (Drosophila); Delta like 1; Delta like 1 protein; Delta like protein 1; Delta like protein 1 precursor; Delta, Drosophila, homolog of 1; Delta-like protein 1; Delta1; DL1; DLL 1; Dll1; DLL1_HUMAN; Drosophila Delta homolog 1; H-Delta-1; OTTHUMP00000017690. |
| 研究领域 | 肿瘤 细胞生物 免疫学 干细胞 转录调节因子 淋巴细胞 b-淋巴细胞 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse (predicted: Human,Rat,Dog,Pig,Rabbit,Zebrafish) |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 76kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DLL1: 101-200/723 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. Delta is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis, and in adult heart and lung. Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Subunit: Interacts with Notch receptors. Subcellular Location: Membrane. Tissue Specificity: Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Post-translational modifications: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. Similarity: Contains 1 DSL domain. Contains 8 EGF-like domains. SWISS: O00548 Gene ID: 28514 Database links: Entrez Gene: 28514 Human Entrez Gene: 13388 Mouse Omim: 606582 Human SwissProt: O00548 Human SwissProt: Q61483 Mouse Unigene: 379912 Human Unigene: 4875 Mouse Unigene: 10628 Rat |
| 产品图片 |
Sample:
Lung (Mouse) Lysate at 40 ug Primary: Anti-DLL1 (bs-21907R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 76 kD Observed band size: 76 kD 
Sample:
Pancreas (Mouse) Lysate at 40 ug Lung (Mouse) Lysate at 40 ug Primary: Anti-DLL1 (bs-21907R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 76 kD Observed band size: 76 kD |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
