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2,3-DCPE hydrochloride (D50449)  
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5mg/800.00元
大包装/询价
产品编号 D50449
英文名称 2,3-DCPE hydrochloride
中文名称 2,3-DCPE盐酸盐
别    名 2,3-DCPE;   
克 隆 号
CAS 418788-90-6
理论分子量 kDa
检测分子量
保存条件 Store at -20℃.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 CAS号:418788-90-6
分子式:C11H15Cl2NO2.HCl
分子量:300.61
纯度:99%(HPLC)
熔点:139-142℃
沸点:429.8℃ at 760 mmHg
溶解性:Soluble in water (>25 mg/ml), ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and PBS (pH7.2) (~10 mg/ml).
产品描述:2,3 DCPE displays anticancer agent properties and induces ERK activation. Causes apoptosis in many tumor cell lines and is known to specifically cleave caspase-8, caspase-3, caspase-9, and poly(ADP-ribose) polymerase in cancer cells, but not in human fibroblasts. Shown to reduce the protein level of Bcl-XL. Triggered cell death in OAW42-R ovarian carcinoma cells with inhibition of Bcl-2 expression and increased cytotoxic effect of cisplatin in OAW42-R resistant cells. 2,3-DCPE reported to induce S-phase arrest and upregulate p21.
IC50:LoVo colon cancer cell line: IC50 = 0.89 µM (human); normal fibroblasts: IC50 = 12.6 µM (human)
用途:A compound that induces both upregulation and S-phase arrest in p21.

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