| 产品编号 |
bs-41361P |
| 英文名称 |
Recombinant human TMPRSS2 protein
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| 中文名称 |
重组人丝氨酸蛋白酶10 |
| 别 名 |
Epitheliasin; PRSS10; Serine protease 10; TMPRSS2; TMPRSS2 ERG FUSION GENE, INCLUDED; TMPRSS2 ETV1 FUSION GENE, INCLUDED; TMPS2_HUMAN; Transmembrane protease serine 2 catalytic chain; Transmembrane protease, serine 2; Transmembrane protease, serine 2, EC 3.4.219; Transmembrane protease, serine 2, EC 3.4.219; D16Ertd61e. |
| 克 隆 号 |
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| 理论分子量 |
44.8 kDa |
| 检测分子量 |
40 |
| 性 状 |
Lyophilized or Liquid |
| 浓 度 |
>0.5 mg/ml |
| 序 列 |
108-492/492 |
| 纯 度 |
>90% by SDSD-PAGE |
| 内毒素 |
Not analyzed |
| 活性 |
No tested |
| 标签 |
N-His Tag |
| 缓 冲 液 |
PBS pH7.5. |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors (1,2). The TMPRSS2 gene encodes a 492 amino acid multimeric serine protease, which is mainly expressed in the mouse prostate and kidney, and is also expressed in the human small intestine, prostate, colon, stomach and salivary gland (3,4). TMPRSS2 contains several domains, including a serine protease domain of the S1 family, a scavenger receptor cysteine-rich domain of group A, an LDL receptor class A domain and a transmembrane domain (3). TMPRSS2 is expressed as a full length form and a cleaved protease domain (5) and its expression is increased by androgenic hormones. TMPRSS2 is also expressed in prostate carcinoma, suggesting that it may play a role in prostate carcinogenesis (6).
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| 产品图片 |
The purity of the protein is greater than 86% as determined by reducing SDS-PAGE.
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