| 产品编号 |
bs-48033P |
| 英文名称 |
Recombinant human IL-21 protein (Active, HEK293)
|
| 中文名称 |
重组人白介素-21（活性的） |
| 别 名 |
Human IL-21；IL-21；h-IL-21；rh-IL-21；recombinant human IL-21；recombinant IL-21；IL；interluekin;Recombinant human IL-21 protein (Active, HEK293) |
| 克 隆 号 |
|
| 理论分子量 |
kDa |
| 检测分子量 |
15 |
| 性 状 |
Lyophilized |
| 浓 度 |
＞0.5 mg/ml |
| 物 种 |
Human |
| 序 列 |
1-132/162 |
| 纯 度 |
>95% as determined by SDS-PAGE |
| 纯化方法 |
AC |
| 内毒素 |
<0.5 EU/μg as determined by LAL. |
| 表达系统 |
HEK293 cell |
| 活性 |
Yes |
| 标签 |
Tag free |
| 保存条件 |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -80℃ under sterile conditions after r |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
IL-21 is a typical family I cytokine with broad pleiotropic actions and is primarily produced by T follicular helper cells, Th17, and natural killer T cells in response to antigenic stimulation. Il-21 generally enhances antigen-specific responses of immune cells. It controls the activation, proliferation, differentiation, cytotoxicity, and survival of various target immune cells. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 elicits its effect through binding to IL-21R, which also contains the gamma chain found in other cytokine receptors such as IL-2, IL-4, IL-7, IL-9 and IL-15. IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues.
|
|
|
