| 产品编号 |
bs-48036P |
| 英文名称 |
Recombinant human EPO protein (Active, HEK293)
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| 中文名称 |
重组人促红细胞生成素C-hFc（活性的） |
| 别 名 |
EPO_HUMAN; Erythropoietin; Epoetin; EP; DBAL; ECYT5; MVCD2; 人促红细胞生成素; 人促红细胞生成素重组蛋白; 重组人促红细胞生成素; 人重组人促红细胞生成素; 重组人EPO; |
| 克 隆 号 |
|
| 理论分子量 |
kDa |
| 检测分子量 |
54-67 |
| 性 状 |
Lyophilized |
| 浓 度 |
＞0.5 mg/ml |
| 物 种 |
Human |
| 序 列 |
1-193/193 |
| 纯 度 |
>95% as determined by SDS-PAGE |
| 纯化方法 |
AC |
| 内毒素 |
<0.5 EU/μg as determined by LAL. |
| 表达系统 |
HEK293 cell |
| 活性 |
Yes |
| 标签 |
Tag free |
| 保存条件 |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -80℃ under sterile conditions after r |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. It also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. It is produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals. Genetic variation in erythropoietin is associated with susceptbility to microvascular complications of diabetes type 2. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. It has a longer circulating half-life in vivo. Erythropoietin is being much misused as a performance-enhancing drug in endurance athletes.
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