| 产品编号 |
bs-42103P |
| 英文名称 |
Recombinant mouse LRP2 protein, N-His
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| 中文名称 |
重组小鼠糖蛋白gp330蛋白 |
| 别 名 |
Calcium sensor protein; DBS; Glycoprotein 330; gp330; Heymann nephritis antigen homolog; Low-density lipoprotein receptor-related protein 2; LRP-2; Lrp2; LRP2_HUMAN. |
| 克 隆 号 |
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| 理论分子量 |
17.7 kDa |
| 检测分子量 |
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| 性 状 |
Lyophilized or Liquid |
| 浓 度 |
1mg/ml |
| 物 种 |
Mouse |
| 序 列 |
4551-4660/4660 |
| 纯 度 |
>90% as determined by SDS-PAGE |
| 内毒素 |
Not analyzed |
| 表达系统 |
E.coli |
| 活性 |
Not tested |
| 标签 |
N-His |
| 缓 冲 液 |
10mM PB (pH7.4). |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009].
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| 产品图片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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