| 产品编号 |
bs-42077P |
| 英文名称 |
Recombinant human ARHGAP24 protein, C-His
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| 中文名称 |
重组人Rho GTP酶激活蛋白24 |
| 别 名 |
ARHGAP24; Filamin A associated RhoGAP; FILGAP; p73; p73RhoGAP; RAC1 and CDC4 specific GTPase activating protein of 72kDa; RCGAP72; Rho GTPase activating protein 24; Rho type GTPase activating protein 24; Rho GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY SAR 88; RHG24_HUMAN. |
| 理论分子量 |
24.3 kDa |
| 检测分子量 |
|
| 性 状 |
Lyophilized or Liquid |
| 浓 度 |
>1mg/ml |
| 物 种 |
Human |
| 序 列 |
1-202/748 |
| 纯 度 |
>90% as determined by SDS-PAGE |
| 内毒素 |
Not analyzed |
| 表达系统 |
E.coli |
| 活性 |
Not tested |
| 缓 冲 液 |
10mM Tris-HCL (pH=10.0)with 0.5M NaCL 2.5M Urea. |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
ARHGAP24 is a rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. It acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. It controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. There are five different isoforms.Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells and is involved in modulation of angiogenesis.
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| 产品图片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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