| 产品编号 |
bs-43562P |
| 英文名称 |
Recombinant human TNFRSF14 protein, C-His (HEK293)
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| 中文名称 |
重组人TNFRSF14蛋白 |
| 别 名 |
HVEM; Tumor necrosis factor receptor superfamily member 14; HveA1; Tumor necrosis factor receptor-like 2; TR21; CD270; Herpesvirus entry mediator A; TNR14_HUMAN. Similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen); CD258; CD258 antigen; CD40 like protein precursor; Herpesvirus entry mediator; Herpesvirus entry mediator ligand; HVEA; HVEM L; HVEML; LIGHT; LIGHTR; TNFSF 14; TR2; UNQ329/PRO509 |
| 克 隆 号 |
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| 理论分子量 |
18.4 kDa |
| 检测分子量 |
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| 性 状 |
Lyophilized or Liquid |
| 浓 度 |
>0.72mg/ml |
| 物 种 |
Human |
| 序 列 |
39-202/283 |
| 纯 度 |
>90% as determined by SDS-PAGE |
| 纯化方法 |
AC |
| 内毒素 |
Not analyzed |
| 表达系统 |
HEK293 cell |
| 活性 |
Not tested |
| 标签 |
C-His |
| 缓 冲 液 |
PBS (pH7.4). |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.
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| 产品图片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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