| 产品编号 |
bs-41327P |
| 英文名称 |
Recombinant human ZO-1 protein, His
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| 中文名称 |
重组胞质紧密粘连蛋白1 |
| 别 名 |
Na Cl symporter; Na-Cl symporter; NaCl electroneutral thiazide sensitive cotransporter; NCCT; S12A3_HUMAN; slc12a3; Solute carrier family 12 (sodium/chloride transporters) member 3; Solute carrier family 12 member 3; Thiazide sensitive Na Cl cotransporter; Thiazide sensitive sodium chloride cotransporter; Thiazide-sensitive sodium-chloride cotransporter; TSC; Recombinant human SLC12A3 protein, N-His Tag |
| 克 隆 号 |
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| 理论分子量 |
33.2 kDa |
| 检测分子量 |
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| 性 状 |
Lyophilized or Liquid |
| 浓 度 |
>0.5mg/ml |
| 物 种 |
Human |
| 纯 度 |
>90% as determined by SDS-PAGE |
| 表达系统 |
E.coli |
| 活性 |
Not tested |
| 标签 |
N-His |
| 缓 冲 液 |
20mM Tris (pH8.0). |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
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| 产品图片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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