| 产品编号 |
bs-46110P-Bio |
| 英文名称 |
Recombinant human ACE2 protein, C-His (HEK293), Biotin conjugated
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| 中文名称 |
生物素化重组血管紧张素转换酶2 |
| 别 名 |
ACE-2; ACE 2; Angiotensin converting enzyme 2; ACE related carboxypeptidase; ACEH; Angiotensin converting enzyme homolog; Angiotensin converting enzyme like protein; Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2; Angiotensin I converting enzyme 2; DKFZP434A014; EC 3.4.17; OTTHUMP00000022963; angiotensin-converting enzyme 2 precursor; ACE2_HUMAN; Angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; Metalloprotease MPROT15; Processed angiotensin-converting enzyme 2; Recombinant human ACE2 protein, C-His (HEK293) / Biotin |
| 克 隆 号 |
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| 理论分子量 |
86.28 kDa |
| 检测分子量 |
100-110 |
| 浓 度 |
＞0.5 mg/ml |
| 纯 度 |
>90% as determined by SDS-PAGE |
| 缓 冲 液 |
Lyophilized from 0.22um filtered solution in PBS (pH7.4) with 5mM DTT. Normally 5% trehalose is added as protectant before Lyophilization. |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
合成与降解（Synthesis and Degradation） ACE-2的分布范围比较局限，ACE2主要在心脏、肾脏、睾丸中表达显著，
近来人们发现ACE2也分布在胃肠道、脑和肺脏中。
有关学者在研究心脏和肾脏中发现，ACE2在心肌缺血、肾功能衰竭、动脉粥样硬化和糖尿病并发症中，ACE2对血管紧张素产生和降解过程中有一定的生理作用。
特别是对ACE2在具有生理活性的-活性肽产生过程中的作用更值得进一步研究。 ACE2的发现为心血管病和肾脏病研究开辟了新天地，并提供了新的治疗靶
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