| 产品编号 | bs-105170P |
| 英文名称 | Recombinant Human FLG Protein, C-His |
| 中文名称 | |
| 别 名 | FLG; Filaggrin |
| 克 隆 号 | |
| 理论分子量 | 35.3 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]. SWISS: P20930 Gene ID: 2312 细胞膜受体（Membrane Receptors)丝聚合蛋白是存在于人表皮角质形成细胞内的一种易溶于水的蛋白，其生成的天然保湿因子(natural moisturizing factor，NMF)对保持皮肤的水合作用及屏障功能至关重要。丝聚合蛋白基因(filaggrin，FLG)位于人类染色体1q21.3区，是表皮分化复合物基因簇的成员之一，与细胞膜形成及表皮终末分化密切相关。FLG基因突变引起的皮肤屏障功能障碍在AD发病中扮演着重要角色，丝聚合蛋白的减少和缺失，可能是引起AD等干燥性皮肤病的主要原因。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
