| 产品编号 | bs-105331P |
| 英文名称 | Recombinant Human LRIG2 Protein, N-His |
| 中文名称 | |
| 别 名 | Leucine-rich repeats and immunoglobulin-like domains protein 2; LIG-2; LRIG2; KIAA0806; LIG2 |
| 克 隆 号 | |
| 理论分子量 | 34.34 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
LRIG2 is produced in all human glioma cell lines and localizes to perinuclear compartments, cytoplasmic compartments and the cell surface. It acts as a negative feedback regulator of signaling through enhanced receptor ubiquitination and accelerated intracellular degradation. LRIG2 may function as a tumour suppressor since it downregulates the expression of EGF and the related proteins ErbB-2, ErbB-3 and ErbB-4, which all inhibit cancer cells from growth, migration and invasion. SWISS: O94898 Gene ID: 9860 LRIG1属于LRIGs基因家族。LRIGs是新发现的一类基因，在哺乳动物体内广泛存在，目前发现该家族至少包括三个成员：LRIG1、LRIG2和LRIG3，是一类结构相似的跨膜糖蛋白，该蛋白人、鼠的同源性较高。 目前在肿瘤方面的研究较多，有研究认为：LRIG1是通过下调EGFR的表达来抑制其下游重要信号传导通路的激活而发挥抑癌作用，LRIG1在抑制肿瘤转移中具有重要作用。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
