| 产品编号 | bs-105380P |
| 英文名称 | Recombinant Human UROD Protein, N-His |
| 中文名称 | |
| 别 名 | Uroporphyrinogen decarboxylase; UPD; URO-D; 4.1.1.37; UROD |
| 克 隆 号 | |
| 理论分子量 | 42.95 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
UROD is the fifth enzyme of the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.
Porphyria cutanea tarda is an autosomal dominant disorder characterized by light-sensitive dermatitis and associated with the excretion of large amounts of uroporphyrin in urine. Hepatoerythropoetic porphyria is a form of porphyria cutanae tarda that may also be a manifestation of benign or malignant hepatic tumors. SWISS: P06132 Gene ID: 7389 UROD是一种参与生成血红素分子的酶（血红素-血红素蛋白,主要在血液、骨髓和肝脏中最丰富）。阻断UROD基因的表达-减低血红素蛋白在肿瘤增殖的作用-增加癌细胞的死亡。经研究认为:肿瘤中的UROD浓度比正常组织显著要高,希望UROD抑制剂的出现, 对肿瘤患者的治疗产生一定的作用。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
