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产品中心-北京博奥森生物技术有限公司
Recombinant Human EVI2B Protein, N-His-KSI (bs-105435P)  
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20ug/980.00元
50ug/1880.00元
100ug/2680.00元
大包装/询价
产品编号 bs-105435P
英文名称 Recombinant Human EVI2B Protein, N-His-KSI
中文名称
别    名 Protein EVI2B; Ecotropic viral integration site 2B protein homolog; EVI-2B; CD361; EVI2B; EVDB  
克 隆 号
理论分子量 28.61 kDa
性    状 Lyophilized
纯    度 >90% as determined by SDS-PAGE.
缓 冲 液 Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
保存条件 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 EVI2B is a 448 amino acid protein which functions in the differentiation of melanocytes and keratinocytes. Lying within an intron of the Neurofibromin gene, the gene encoding EVI2B is transcribed from the telomere toward the centromere, which is opposite the transcription direction of the Neurofibromin gene. EVI2B is a single-pass transmembrane protein containing an extracellular domain with 4 glycosylation sites, a N-terminal signal peptide, a cytoplasmic hydrophilic domain and a hydrophobic transmembrane domain. Due to evidence suggesting that gene encoding the mouse homolog lies within a viral integration site that has been identitified in retrovirus-induced myeloid tumors, the gene encoding EVI2B may function as an oncogene in these tumor types. With expression in peripheral blood mononuclear cells, fibroblasts, bone marrow and EBV-transformed lymphoblastoid cell lines, EVI2B is implicated in leukemogenesis.

SWISS:
P34910

Gene ID:
2124

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