| 产品编号 |
bs-42633P |
| 英文名称 |
Recombinant mouse Bcl-2 protein, N-His
|
| 中文名称 |
重组小鼠Bcl-2蛋白 |
| 别 名 |
Bcl-2; PPP1R50; BCL2_MOUSE; BCL2; |
| 理论分子量 |
25.5kDa |
| 性 状 |
Liquid |
| 浓 度 |
>1mg/ml |
| 纯 度 |
>90% as determined by SDS-PAGE |
| 缓 冲 液 |
20mM Tris-Hcl (pH=8.0) with 150mM NaCL |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).
Bcl-2基因是指B-cell lymphoma gene。人体滤泡B细胞淋巴瘤中过量表达的原癌基因。由于染色体t（14；18）易位，将Bcl-2基因置于免疫球蛋白重链的转录调控下，使其表达失控。在细胞系中其过量表达能延长细胞存活期而不诱导细胞增殖。它是哺乳动物中细胞调亡的抑制基因。参与细胞凋亡的调控。肿瘤中的Bcl-2基因可提高侵润性瘤细胞的生存能力。主要用于滤胞型淋巴瘤、毛细管性白血病及细胞凋亡等方面的研究。
目前研究认为：Bcl-2也是细胞凋亡的一种抑制因子、参与细胞凋亡调控，可以用于各种恶性肿瘤
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