| 产品编号 | bsm-63843R |
| 英文名称 | CYLD Recombinant Rabbit mAb |
| 中文名称 | |
| 别 名 | CYLD_BOVIN; CYLD; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD; 3.4.19.12; CYLD1; CYLD_HUMAN; KIAA0849; CYLD_MOUSE; CYLD_RAT; CYLD lysine 63 deubiquitinase; cylindromatosis (turban tumor syndrome); ubiquitin specific peptidase like 2; Ubiquitin carboxyl-terminal hydrolase CYLD |
| 抗体来源 | Rabbit |
| 克隆类型 | Recombinant |
| 克 隆 号 | 2A4 |
| 交叉反应 | Human,Mouse,Rat |
| 产品应用 | WB=1:2000-10000,IHC-P=1:200-1000,IHC-F=1:200-1000,IF=1:200-1000,ELISA=1:5000-20000,IP=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 |
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008], SWISS: Q9NQC7 Gene ID: 1540 CYLD(cylindromatosis)是近年发现的一种肿瘤抑制基因,CYLD丢失或突变可致肿瘤形成,多个研究显示,其表达蛋白CYLD可去泛素化TRAFs、NEMO、Bcl-3及p53等信号分子,调控细胞NF-κB和JNK等信号途径,CYLD在人体内广泛分布，在细胞周期的调控、介导细胞凋亡、抑制肿瘤发生等分子事件中有着重要的调控作用。 CYLD基因缺陷或缺失主要导致头部或面部的皮肤肿瘤,如多发性家族性毛发上皮瘤(MFT),家族性圆柱瘤(FC)和Brooke-Spiegler综合症(BSS |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
